ReviewGeneral psychiatry2021
Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.
Review in General psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive functioning in adolescents with internalizing disorders: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Developmental Stage Differences in the Childhood Trauma-Adolescent Anxiety Network: A Large-Scale Cross-Sectional Application of Network Temperature.Child psychiatry and human development · 2026Article
- Reward processing differences in autism: current understandings and future directions.Social cognitive and affective neuroscience · 2026Review
- Neuroanatomical correlates of communication apprehension in young adults using voxel-based morphometry.Scientific reports · 2026Article
- Socio-cultural context as a protective factor: regional disparities in adolescent mental health in Mexico during the COVID-19 pandemic.Frontiers in child and adolescent psychiatry · 2026Article
- Neural mechanisms of uncertain decision-making in anxious adolescents: an EEG study based on the balloon analogue risk task.Frontiers in psychiatry · 2026Article
- Network Analysis of Symptom-Level Interrelationships Between Adverse Childhood Experiences and Insomnia Symptoms in Adolescents: A Large-Sample Study.Nature and science of sleep · 2026Article
- The 'hand-brain-emotion' axis: a theoretical model for handicraft art-based intervention in anxiety disorders through neuroplasticity and autonomic regulation.Frontiers in psychology · 2026Review
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- Adolescent screen time, anxiety/depression, and alcohol/e-cigarette use: evidence from the ABCD study.BMC public health · 2025Article
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.Development and psychopathology · 2025Article
- Perceived Mother and Father Parenting and Adolescent Social Anxiety Symptoms: A Meta-Analysis.Adolescent research review · 2025Article
- Trauma and anxiety interactions relate to reward processing in adolescents.Journal of affective disorders · 2025Article
- Which panic-agoraphobic symptoms could be associated with the presence of autistic traits among patients with panic disorder?CNS spectrums · 2025Article
- Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles.BMC medical ethics · 2025Article
- National trends of mental health and service utilisation among international students in the USA, 2015-2024.General psychiatry · 2025Article
- Psychological functioning of patients with type I diabetes: the relevant role of alexithymia and intolerance to uncertainty.Frontiers in psychiatry · 2025Article
- Social isolation increases impulsive choice with minor changes on metabolic function in middle-aged rats.Physiological reports · 2025Article
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescence is the peak period for the incidence of anxiety disorders. Recent findings have revealed the immaturity of neural networks underlying emotional regulation in this population. Brain vulnerability to anxiety in adolescence is related to the unsynchronised development of anxiety-relevant brain functional systems. However, our current knowledge on brain deficits in adolescent anxiety is mainly borrowed from studies on adults. Understanding adolescent-specific brain deficits is essential for developing biomarkers and brain-based therapies targeting adolescent anxiety. This article reviews and compares recent neuroimaging literature on anxiety-related brain structural and functional deficits between adolescent and adult populations, and proposes a model highlighting the differences between adolescence and adulthood in anxiety-related brain networks. This model emphasises that in adolescence the emotional control system tends to be hypoactivated, the fear conditioning system is immature, and the reward and stress response systems are hypersensitive. Furthermore, the striatum's functional links to the amygdala and the prefrontal cortex are strengthened, while the link between the prefrontal cortex and the amygdala is weakened in adolescence. This model helps to explain why adolescents are vulnerable to anxiety disorders and provides insights into potential brain-based approaches to intervene in adolescent anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.