Evidence map›Paper›PMID 34423116›Full record

ArticleSmall methods2021

An

Zhuoyu Zhang, Lunan Liu, Chao Ma, Xin Cui, Raymond H W Lam, Weiqiang Chen

Open access · greenAbstract read
In one paragraph

Article in Small methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  7. Cell therapies for viral diseases: a new frontier.Seminars in immunopathology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Zhuoyu Zhang *Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.
Lunan Liu *Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.
Chao Ma *Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.
Xin CuiDepartment of Biomedical Engineering, Jinan University, Guangzhou, China.
Raymond H W LamDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Weiqiang ChenDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY.
New York University · USState University of New York · USCity University of Hong Kong · HKJinan University · CN

Funding

Purchase of spinning disk confocal microscopeR35GM133646 · NIGMS · NEW YORK UNIVERSITY · PI CHEN, WEIQIANG · 2019 to 2023
$2.0M
Engineered Glioblastoma Tumor Immunity for Personalized ImmunotherapyR21EB025406 · NIBIB · NEW YORK UNIVERSITY · PI CHEN, WEIQIANG, SNUDERL, MATIJA · 2018 to 2020
$610k
NIBIB NIH HHS R21 EB025406NIGMS NIH HHS R35 GM133646
6 · The paper itself

Abstract

The PD-1 immune checkpoint-based therapy has emerged as a promising therapy strategy for treating the malignant brain tumor glioblastoma (GBM). However, patient response varies in clinical trials due in large to the tumor heterogeneity and immunological resistance in the tumor microenvironment. To further understand how mechanistically the niche interplay and competition drive anti-PD-1 resistance, we established an

Indexed as

computational biologyGlioblastomaimmunotherapyOrgan-on-a-Chiptumor microenvironment

Identifiers

PMID34423116
PMCPMC8372235
OpenAlexW3157824567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.