Evidence map›Paper›PMID 34423115›Full record

ArticleSmall methods2020

Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening.

Li Ren, Xingwu Zhou, Rohollah Nasiri, Jun Fang, Xing Jiang, Canran Wang, Moyuan Qu, Haonan Ling, Yihang Chen, Yumeng Xue and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  4. Article
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  7. Article
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  10. Review
  11. Article
  12. Review
  13. Fabrication and Biomedical Applications of Heart-on-a-chip.International journal of bioprinting · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Li Ren *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xingwu Zhou *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rohollah Nasiri *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jun FangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xing JiangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Canran WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Moyuan QuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Haonan LingDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yihang ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yumeng XueDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Martin C HartelDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Peyton TebonDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shiming ZhangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Han-Jun KimDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xichen YuanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Amir ShamlooDepartment of Mechanical Engineering, Sharif University of Technology, Tehran 11365, Iran.
Mehmet Remzi DokmeciDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Song LiDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ali KhademhosseiniDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Samad AhadianDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wujin SunDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Funding

Research Supplements to Promote DiversityR01GM126571 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOKMECI, MEHMET REMZI, YE, JING YONG · 2018 to 2021
$1.3M
NIGMS NIH HHS R01 GM126571
6 · The paper itself

Abstract

Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market. The establishment of preclinical drug screening platforms that have higher relevancy to physiological conditions is desirable to facilitate drug development. Here, a heart-on-a-chip platform, incorporating microgrooves and electrical pulse stimulations to recapitulate the well-aligned structure and synchronous beating of cardiomyocytes (CMs) for drug screening, is reported. Each chip is made with facile lithographic and laser-cutting processes that can be easily scaled up to high-throughput format. The maturation and phenotypic changes of CMs cultured on the heart-on-a-chip is validated and it can be treated with various drugs to evaluate cardiotoxicity and cardioprotective efficacy. The heart-on-a-chip can provide a high-throughput drug screening platform in preclinical drug development.

Indexed as

cardiotoxicitydrug screeningelectric stimulationheart-on-a-chipmicrogrooves

Identifiers

PMID34423115
PMCPMC8372829

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.