Evidence map›Paper›PMID 34423079›Full record

ArticleTobacco regulatory science2020

Variable Voltage, Tank-Style ENDS Do Not Always Deliver Nicotine.

Alisha Eversole, Sarah Maloney, Soha Talih, Rola Salman, Nareg Karaoghlanian, Thokozeni Lipato, Thomas Eissenberg, Alison Breland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco regulatory science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alisha EversoleAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Sarah MaloneyAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Soha TalihAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Rola SalmanAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Nareg KaraoghlanianAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Thokozeni LipatoAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Thomas EissenbergAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.
Alison BrelandAlisha Eversole, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Sarah Maloney, Graduate Student, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Soha Talih, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Rola Salman, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Nareg Karaoghlanian, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. Thokozeni Lipato, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA. Thomas Eissenberg, Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA. Alison Breland, Associate Professor, Virginia Commonwealth University, Center for the Study of Tobacco Products, Richmond VA.

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI FAGAN, PEBBLES · 2018 to 2022
$20.8M
Training and Education Core p270-287P50DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EISSENBERG, THOMAS EVAN · 2013 to 2017
$19.2M
NIDA NIH HHS P50 DA036105NIDA NIH HHS U54 DA036105
6 · The paper itself

Abstract

objectiveThis study's objective was to characterize the nicotine delivery profile of a variable voltage, tank-style electronic nicotine delivery system (ENDS).

methodsTen cigarette smokers (8 men, 2 women) completed this within-subject study assessing effects of 2 device power settings (15 W, 45 W) and 3 liquid nicotine concentrations (0, 3, and 6 mg/ml) using a tank-style ENDS. Participants completed one directed (10 puffs) and one

resultsPlasma nicotine concentration did not increase significantly at 15 W regardless of liquid nicotine concentration. At 45 W, mean plasma nicotine increased (not significantly compared to 0 mg/ml) from 2.24 ng/ml (SD=0.2) at baseline to 3.4 ng/ml (SD=0.6) in the 3 mg/ml condition. In the 6 mg/ml, 45 W condition, mean plasma nicotine increased significantly (compared to 0 mg/ml) from 2.0 ng/ml (SD=0) at baseline to 5.96 ng/ml (SD=1.3) after 10 puffs. In general, puff duration and volume decreased as device power and nicotine concentration increased.

conclusionsDespite using a variable wattage, tank-style device, nicotine delivery was minimal. These results, when combined with results from other studies using tank-style devices, highlight ENDS performance heterogeneity. Regulation may play a role in standardizing ENDS nicotine delivery.

Indexed as

ENDSnicotine delivery

Identifiers

PMID34423079
PMCPMC8375626

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.