Evidence map›Paper›PMID 34423032›Full record

ArticleBioMed research international2021

Preliminary Evaluation of a Novel Fetal Guinea Pig Myelomeningocele Model.

Sarah C Stokes, Kaeli J Yamashiro, Melissa A Vanover, Laura A Galganski, Jordan E Jackson, Christina M Theodorou, Christopher D Pivetti, Diana Lee Farmer, Aijun Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sarah C StokesDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Kaeli J YamashiroDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Melissa A VanoverDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.ORCID https://orcid.org/0000-0002-5254-1197
Laura A GalganskiDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Jordan E JacksonDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Christina M TheodorouDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Christopher D PivettiDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Diana Lee FarmerDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.
Aijun WangDepartment of Surgery, University of California-Davis, Sacramento, CA, USA.ORCID https://orcid.org/0000-0002-2985-3627
University of California, Davis · USShriners Hospitals for Children - Northern California · US

Funding

Guinea pigs as a model of in utero stem cell therapy for spina bifidaR03HD091601 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2018
$157k
NICHD NIH HHS R03 HD091601
6 · The paper itself

Abstract

introductionTranslational models of myelomeningocele (MMC) are needed to test novel

methodsTime-mated Dunkin Hartley guinea pig dams were dosed with 60 mg/kg of RA between gestation age (GA) 12 and 15 days in the development of an RA model. Fetuses were grossly evaluated for MMC lesions at Cesarean section after GA 31 days. Evaluation of the ability of pregnant guinea pig dams to tolerate uterine surgical intervention was performed by hysterotomy of a separated group of time-mated guinea pigs at GA 45, 50, and 55.

resultsForty-two pregnant guinea pigs were dosed with RA, with a total of 189 fetuses. The fetal demise rate was 38% (

conclusionRA dosed at 60 mg/kg in guinea pigs between GA 12 and 15 did not result in MMC. Dunkin Hartley guinea pigs did not tolerate a hysterotomy near term in our surgical model. Further work is needed to determine if MMC can be induced in guinea pigs with alternate RA dosing.

Indexed as

AnimalsCesarean SectionDisease Models, AnimalFemaleFetal DiseasesGestational AgeGuinea PigsHumansHysterotomyMeningomyelocelePregnancyTretinoinTretinoin

Identifiers

PMID34423032
PMCPMC8378975
OpenAlexW3195306389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.