Evidence map›Paper›PMID 34422977›Full record

ArticleAnnals of translational medicine2021

A bibliometric analysis of Wnt signaling pathway: from the top-100 cited articles to emerging trends.

Jia-Qi Xu, Ning Tang, Ling-Feng Zhang, Chen Tan, Yang Su, Daniel M George, Guang-Xu He, Tian-Long Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Knowledge base and emerging trends in YAP1 research.American journal of translational research · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jia-Qi XuOrthopaedic Department, The Second Xiangya Hospital of Central South University, Changsha, China.
Ning TangOrthopaedic Department, The Second Xiangya Hospital of Central South University, Changsha, China.
Ling-Feng ZhangRoyal Adelaide Hospital, Adelaide, SA, Australia.
Chen TanRoyal Adelaide Hospital, Adelaide, SA, Australia.
Yang SuOrthopaedic Department, The Second Xiangya Hospital of Central South University, Changsha, China.
Daniel M GeorgeXiangya School of Medicine, Central South University, Changsha, China.
Guang-Xu HeOrthopaedic Department, The Second Xiangya Hospital of Central South University, Changsha, China.
Tian-Long HuangOrthopaedic Department, The Second Xiangya Hospital of Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWnt signaling pathway plays a vital role in the regulation of development. An increasing number of articles about Wnt pathway components have been published. By analyzing these studies' characteristics and qualities, we aim to reveal the current research focus and emerging trends in Wnt signaling.

methodsThe databases of Web of Science Core Collection, BIOSIS Citation Index, MEDLINE, etc. were utilized to identify articles on May 23rd, 2020. Wnt signaling pathway-related articles were identified, the 100 most cited articles and articles in the last decade were selected and calculated for citations without self-citation. The subsequent analysis included citation density (citations/article age), time-related flux, authorship, institution, journal, geographic distribution, and theme.

resultsThese articles were published mainly from 2000 to 2009 (62%). Citations per article ranged from 599 to 3,780 with a median number of 880 times. Most studies (66%) came from the United States. Nusse Roel and Clevers Hans (15 and 13 papers) have contributed significantly to the field. The most highlighted study themes were cancer (15%), embryo development (14%), and cytoplasm signal transduction (11%). From 2011 to 2020, interest in emerging subtopics, including osteogenesis, immune, apoptosis, autophagy, microRNA, and cancer stem cell, are rising.

conclusionsCancer, embryo development, stem cell, and signal transduction process still play a major role in the field. With multiple emerging subtopics and investigation on an integrated view of the Wnt signal network, the association of Wnt with diseases was further revealed.

Indexed as

Bibliometric analysiscancercell signalingembryo developmenttop-100 articlesWntβ-catenin

Identifiers

PMID34422977
PMCPMC8339812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.