ArticleAnnals of translational medicine2021
Neutrophil to lymphocyte ratio and adverse clinical outcomes in patients with ischemic stroke.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Article
- Seeing the Small to Prevent the Big: The Role of Cerebral Microvessels in Ischemic Stroke Etiology and Prevention.Stroke research and treatment · 2026Review
- Higher PHQ-9 score levels and neutrophil-to-lymphocyte ratio are associated with increased risks of stroke, all-cause mortality, and MACE in NHANES 2005-2018.BMC psychiatry · 2025Article
- Evaluation of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as prognostic markers in ischemic stroke of diabetic patients: A cross-sectional analysis.Journal of family medicine and primary care · 2025Article
- Immunological and Inflammatory Biomarkers in the Prognosis, Prevention, and Treatment of Ischemic Stroke: A Review of a Decade of Advancement.International journal of molecular sciences · 2025Review
- [Characteristics and clinical significance of neutrophil to lymphocyte ratio in patients with sudden sensorineural hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Neutrophil extracellular traps in ischemic stroke: mechanisms, clinical implications, and therapeutic potential.Frontiers in neurology · 2025Review
- How to predict postoperative delirium in geriatric patients with hip fracture as soon as possible? A retrospective study.BMC surgery · 2024Article
- Neutrophil to lymphocyte ratio and five-year mortality in patients with acute ischemic stroke.Heliyon · 2024Article
- The Prognosis of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Elderly with Acute Ischemic Stroke.Clinical interventions in aging · 2024Article
- Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction.Frontiers in neurology · 2024Article
- The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Predicts the Prognosis of Adults with Status Epilepticus: A Retrospective Study.Journal of inflammation research · 2024Article
- Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic stroke.Frontiers in immunology · 2024Article
- Poststroke neutrophil count is predictive of the outcomes of large-artery atherosclerotic stroke and associated with craniocervical atherosclerosis.Scientific reports · 2023Article
- Preoperative Neutrophil Lymphocyte Ratio in Prediction of Adnexal Mass Torsion.Obstetrics and gynecology international · 2023Article
- Clinical presentation and neurovascular manifestations of cardiac myxomas and papillary fibroelastomas: a retrospective single-institution cohort study.Frontiers in cardiovascular medicine · 2023Article
- Predictive value of neutrophil-to-lymphocyte ratio for atrial fibrillation and stroke in type 2 diabetes mellitus: The Hong Kong Diabetes Study.Endocrinology, diabetes & metabolism · 2023Article
- Baseline Objective Malnutritional Indices as Immune-Nutritional Predictors of Long-Term Recurrence in Patients with Acute Ischemic Stroke.Nutrients · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeutrophils and lymphocytes mediate differential inflammatory responses after ischemic stroke and have different effects on patients' clinical outcomes. Several studies have used the neutrophil to lymphocyte ratio (NLR) as a prognostic indicator for ischemic stroke; however, some limitations remain.
methodsWe derived data from the Third China National Stroke Registry. The NLR is defined as neutrophil count/lymphocyte count. Patients included in the study were classified into four groups by NLR quartiles. Odds ratios (ORs) of adverse clinical outcomes were calculated with the lowest quartile group as the reference category. We plotted receiver operating characteristic (ROC) curves of NLR for adverse clinical outcomes and calculated area under the curve (AUC) values and cutoff values. Under different TOAST classifications, medians of NLR and ORs of adverse clinical outcomes were also calculated. Furthermore, interaction tests between NLR and etiology were performed.
resultsA total of 13,018 patients were enrolled. At both 3- and 12-month follow-ups, higher quartile groups were associated with increased risks of death and poor functional outcomes, even after adjustments. For death, the cutoff values of NLR were 3.872 at 3-month follow-up and 3.180 at 12-month follow-up. For poor functional outcomes, the cutoff value of NLR was 2.846 at both 3- and 12-month follow-ups. The association between NLR and stroke recurrence was significant only at 3-month follow-up before adjustments. There was no correlation between NLR and hemorrhagic transformation during hospitalization. Under different TOAST classifications, the medians of NLR were different; conversely, the correlations of NLR with adverse clinical outcomes had no differences.
conclusionsHigh level of NLR within the first 24 h after admission was associated with increased risks of both short- and long-term adverse clinical outcomes in patients with ischemic stroke, regardless of etiology.
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