Evidence map›Paper›PMID 34422930›Full record

SynthesisFrontiers in cardiovascular medicine2021

Antithrombotic Treatment After Surgical and Transcatheter Heart Valve Repair and Replacement.

Andreas Verstraete, Marie Christine Herregods, Peter Verbrugghe, Marie Lamberigts, Thomas Vanassche, Bart Meyns, Wouter Oosterlinck, Filip Rega, Tom Adriaenssens, Lucas Van Hoof and 7 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Advances in diagnosis and treatment of mechanical hemolysis following percutaneous interventional for valvular heart diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andreas VerstraeteDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Marie Christine HerregodsDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Peter VerbruggheDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Marie LamberigtsDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Thomas VanasscheDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Bart MeynsDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Wouter OosterlinckDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Filip RegaDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Tom AdriaenssensDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Lucas Van HoofDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Siegmund KeuleersDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Christophe VandenbrieleDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Peter SinnaeveDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Stefan JanssensDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Christophe DuboisDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Bart MeurisDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Peter VerhammeDepartment of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New antithrombotic drugs have been developed, new valve types have been designed and minimally invasive transcatheter techniques have emerged, making the choice of antithrombotic therapy after surgical or transcatheter heart valve repair and replacement increasingly complex. Moreover, due to a lack of large randomized controlled trials many recommendations for antithrombotic therapy are based on expert opinion, reflected by divergent recommendations in current guidelines. Therefore, decision-making in clinical practice regarding antithrombotic therapy for prosthetic heart valves is difficult, potentially resulting in sub-optimal patient treatment. This article compares the 2017 ESC/EACTS and 2020 ACC/AHA guidelines on the management of valvular heart disease and summarizes the available evidence. Finally, we established a convenient consensus on antithrombotic therapy after valve interventions based on over 800 annual cases of surgical and transcatheter heart valve repair and replacement and a multidisciplinary team discussion between the department of cardiovascular diseases and cardiac surgery of the University Hospitals Leuven, Belgium.

Indexed as

anTithrombotic treatmentsurgical valve repairsurgical valve replacementtranscatheter aortic valve implantationtranscatheter valve repairtranscatheter valve replacementvalve interventionvalvular heart disease

Identifiers

PMID34422930
PMCPMC8375148

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.