Evidence map›Paper›PMID 34422802›Full record

ReviewFrontiers in cell and developmental biology2021

Role of Long Non-coding RNAs on Bladder Cancer.

Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. LncRNAJournal of Cancer · 2025
    Article
  8. Involvement of lncRNA in cancer diagnosis and prognosis and clinical implications.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  15. An Overview of Angiogenesis in Bladder Cancer.Current oncology reports · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. mTheranostics · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hui-Jin LiShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Xue GongShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Zheng-Kun LiCollege of Medical Technology, Xi'an Medical University, Xi'an, China.
Wei QinShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Chun-Xia HeShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Lu XingShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Xin ZhouShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Dong ZhaoShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Hui-Ling CaoShaanxi Key Laboratory of Ischemic Cardiovascular Disease, and Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Xi'an Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) is the most common malignant tumor in the urinary system, and its early diagnosis is conducive to improving clinical prognosis and prolonging overall survival time. However, few biomarkers with high sensitivity and specificity are used as diagnostic markers for BC. Multiple long non-coding RNAs (lncRNAs) are abnormally expressed in BC, and play key roles in tumorigenesis, progression and prognosis of BC. In this review, we summarize the expression, function, molecular mechanisms and the clinical significance of lncRNAs on bladder cancer. There are more than 100 dysregulated lncRNAs in BC, which are involved in the regulation of proliferation, cell cycle, apoptosis, migration, invasion, metabolism and drug resistance of BC. Meanwhile, the molecular mechanisms of lncRNAs in BC was explored, including lncRNAs interacting with DNA, RNA and proteins. Additionally, the abnormal expression of thirty-six lncRNAs is closely associated with multiple clinical characteristics of BC, including tumor size, metastasis, invasion, and drug sensitivity or resistance of BC. Furthermore, we summarize some potential diagnostic and prognostic biomarkers of lncRNA for BC. This review provides promising novel biomarkers in early diagnosis, prognosis and monitoring of BC based on lncRNAs.

Indexed as

biomarkerbladder cancer (BC)early diagnosislong non-coding RNAs (lncRNAs)tumor development

Identifiers

PMID34422802
PMCPMC8371405
OpenAlexW3192651840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.