Evidence map›Paper›PMID 34422801›Full record

ArticleFrontiers in cell and developmental biology2021

TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development.

Thomas H Shin, Evangelos Theodorou, Carl Holland, Rae'e Yamin, Cathleen L Raggio, Philip F Giampietro, David A Sweetser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Thomas H ShinDepartment of Pediatrics, Center of Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Evangelos TheodorouDepartment of Pediatrics, Center of Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Carl HollandDepartment of Pediatrics, Center of Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Rae'e YaminDepartment of Pediatrics, Center of Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Cathleen L RaggioDepartment of Pediatric Orthopedics, Hospital for Special Surgery, New York, NY, United States.
Philip F GiampietroDepartment of Pediatrics, University of Illinois, Chicago, IL, United States.
David A SweetserDepartment of Pediatrics, Center of Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Massachusetts General Hospital · USHarvard University · USHospital for Special Surgery · USUniversity of Illinois Chicago · US

Funding

Molecular Analysis of Del(9q) Acute Myeloid LeukemiaR01CA115772 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SWEETSER, DAVID A · 2006 to 2010
$2.0M
Functional Analysis of Whole Exome Sequence Variants Identified in Patients with Vertebral MalformationsR03HD099516 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GIAMPIETRO, PHILIP F · 2020 to 2021
$247k
NCI NIH HHS R01 CA115772NICHD NIH HHS R03 HD099516
6 · The paper itself

Abstract

Healthy bone homeostasis hinges upon a delicate balance and regulation of multiple processes that contribute to bone development and metabolism. While examining hematopoietic regulation by

Indexed as

bone calcificationbone mineralizationosteoblastRunx2Tle4Tle4-Runx axis

Identifiers

PMID34422801
PMCPMC8377417
OpenAlexW3191677635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.