Evidence map›Paper›PMID 34422789›Full record

ArticleFrontiers in cell and developmental biology2021

Dual DNA Transfection Using 1,6-Hexanedithiol-Conjugated Maleimide-Functionalized PU-PEI

Chian-Shiu Chien, Yueh Chien, Yi-Ying Lin, Ping-Hsing Tsai, Shih-Jie Chou, Aliaksandr A Yarmishyn, Elham Rastegari, Ting-Xian Wang, Hsin-Bang Leu, Yi-Ping Yang and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Chian-Shiu ChienDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Yueh ChienDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Ying LinDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Ping-Hsing TsaiDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Shih-Jie ChouDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Aliaksandr A YarmishynDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Elham RastegariDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Ting-Xian WangDepartment of Chemistry and Biochemistry, National Chung-Cheng University, Chiayi County, Taiwan.
Hsin-Bang LeuSchool of Medicine, National Yang-Ming Medical University, Taipei, Taiwan.
Yi-Ping YangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Mong-Lien WangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Ying-Chun JhengDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Henkie Isahwan Ahmad Mulyadi LaiInstitute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
Lo-Jei ChingDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Teh-Ia HuoDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Jong-Yuh CherngDepartment of Chemistry and Biochemistry, National Chung-Cheng University, Chiayi County, Taiwan.
Chien-Ying WangSchool of Medicine, National Yang-Ming Medical University, Taipei, Taiwan.
Taipei Veterans General Hospital · TWNational Yang Ming Chiao Tung University · TWTaipei Medical University · TWNational Chung Cheng University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-viral gene delivery holds promises for treating inherited diseases. However, the limited cloning capacity of plasmids may hinder the co-delivery of distinct genes to the transfected cells. Previously, the conjugation of maleimide-functionalized polyurethane grafted with small molecular weight polyethylenimine (PU-PEI

Indexed as

cardiomyopathyCRISPR/Cas9Fabry diseaseGLAinduced pluripotent stem cellspolyethyleneiminepolyurethane

Identifiers

PMID34422789
PMCPMC8371449
OpenAlexW3192355659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.