ArticleAnalytical cellular pathology (Amsterdam)2021
Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations.
Article in Analytical cellular pathology (Amsterdam), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Real world lessons on tyrosine kinase inhibitor response and resistance in CML from a developing country Pakistan.Pakistan journal of medical sciences · 2026Article
- Nonclassical Philadelphia-positive FISH signal patterns in CML and seven cases with variant Philadelphia.Turkish journal of medical sciences · 2026Article
- Study of the association between HDAC8, SIRT1, and P53 gene expression with drug resistance in chronic myeloid leukemia patients.BMC cancer · 2025Article
- The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia.Journal of hematopathology · 2024Article
- COVID-19 Impact on Chronic Myeloid Leukemia Patients.Journal of personalized medicine · 2022Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
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Abstract
Chronic myeloid leukemia (CML) is a disease of hematopoietic stem cells and is caused by the balanced translocations among the long arms of chromosomes 9 and 22, which are called the Philadelphia (Ph) chromosome. In this study, 131 CML patients were enrolled. Complete blood cell count was performed at the time of diagnosis for all the patients. Cytogenetic (karyotyping) examination using bone marrow samples was conducted on 76 CML patients for the confirmation of Ph-positive (9;22)(q34;q11) standard translocation, complex variant translocation, and additional chromosome abnormalities. FISH was performed on 38 patients for diagnostic purposes and on 39 patients for monitoring purposes. Twenty-two samples of CML patients were evaluated by reverse transcriptase PCR and real-time PCR for the patients who failed to respond against imatinib mesylate. In this study, 72 (54.96%) were males and 59 (45.03%) were females with a median age of 38.5 years. CBC values in the diagnosis process showed that 75 patients had high values of WBC being >100 × 10
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