Evidence map›Paper›PMID 34422488›Full record

ArticleCureus2021

Intravascular Large B-Cell Lymphoma: A Diagnostic Dilemma.

Arya Mariam Roy, Yadav Pandey, Derek Middleton, Brannon Broadfoot, Appalanaidu Sasapu, Muthu Veeraputhiran

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Case Report: Neuropsychological Profile of a Patient With Intravascular Large B-Cell Lymphoma Following Infection and Vaccination.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arya Mariam RoyDepartment of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.
Yadav PandeyDepartment of Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.
Derek MiddletonDepartment of Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.
Brannon BroadfootDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA.
Appalanaidu SasapuDepartment of Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.
Muthu VeeraputhiranDepartment of Hematology and Medical Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.
University of Arkansas for Medical Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravascular large B-cell lymphoma is a rare malignancy characterized by the presence of lymphoma cells within the lumen of blood vessels. The annual incidence of cases is fewer than 0.5 cases per 1,000,000. It usually affects the elderly with an average age of diagnosis around 70 years. Due to the absence of lymphoma cells in the peripheral smear and lymphadenopathy, it is difficult to diagnose these cases. Although the central nervous system and skin are the commonly involved organs, they can involve any organ system. Prompt diagnosis and initiation of treatment are very crucial as it carries a high mortality. We describe two patients who presented with constitutional symptoms and fever of unknown origin, later diagnosed as intravascular large B- cell lymphoma. The diagnosis was difficult in both cases as the presenting symptoms were atypical. One of the patients was diagnosed at autopsy. The delay in diagnosis often leads to fatal outcomes as the disease is very aggressive. A high degree of clinical suspicion is the key to prompt diagnosis and improved outcomes.

Indexed as

bone marrow biopsyb-symptomsdiffuse large b cell lymphomafever of unknown originintravascular large b-cell lymphomaintravascular lymphomarituximab

Identifiers

PMID34422488
PMCPMC8370572
OpenAlexW3185918762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.