Evidence map›Paper›PMID 34422411›Full record

ArticleInternational journal of surgical oncology2021

Transition to Targeted Therapies Improved the Prognosis and Increased the Utilization of Medical Treatments among Patients with Synchronous Metastatic Renal Cell Cancer.

Lauri Laru, Hanna Ronkainen, Markku H Vaarala

Open access · hybridAbstract read
In one paragraph

Article in International journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lauri LaruDepartment of Surgery, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, P.O. Box 21, 90029 OYS, Oulu, Finland.
Hanna RonkainenDepartment of Surgery, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, P.O. Box 21, 90029 OYS, Oulu, Finland.
Markku H VaaralaDepartment of Surgery, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, P.O. Box 21, 90029 OYS, Oulu, Finland.ORCID https://orcid.org/0000-0003-4735-815X
Oulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the introduction of targeted therapies (TTs) for metastatic renal cell cancer (mRCC) in 2005, a limited amount of epidemiological data on efficacy of modern drug therapies for synchronous mRCC has been published. We present a comprehensive nationwide cohort including all cases of primarily metastasized renal cell cancer among adults diagnosed between 2005 and 2010, based on data from the Finnish Cancer Registry and patient records from treating hospitals. Applied treatment protocols and survival outcomes were analyzed. A total of 977 patients were included in the analysis; 499 patients were diagnosed between 2005 and 2007 and 478 patients were diagnosed between 2008 and 2010. The median overall survival (OS) was 8.80 months (95% confidence interval (CI): 7.60-10.02). The median OS of the patients diagnosed at the latter era was significantly better (11.1; 95% CI: 8.8-13.4 vs. 7.0; 95% CI: 5.7-8.3 months,

Indexed as

Carcinoma, Renal CellKidney NeoplasmsNeoplasms, Multiple PrimaryAgedHumansMolecular Targeted TherapyPrognosisTreatment OutcomeVascular Endothelial Growth Factor AVascular Endothelial Growth Factor A

Identifiers

PMID34422411
PMCPMC8378950
OpenAlexW3194491277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.