Evidence map›Paper›PMID 34422405›Full record

ArticleJournal of ophthalmology2021

A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression.

Xie-He Kong, Yue Zhao, Zhi Chen, Li Zeng, Rong Han, Xiao-Qing Dong, Xiao-Cong Guo, Zheng Shi, Guang Yang, Yan-Ting Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Current Evidence on Options and Efficacy of Combination Therapy for Myopia Control-A Narrative Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  7. Review
  8. Review
  9. Review
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  11. IMI 2023 Digest.Investigative ophthalmology & visual science · 2023
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xie-He KongShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-8778-7445
Yue ZhaoShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-1589-6351
Zhi ChenDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.ORCID https://orcid.org/0000-0002-9038-4831
Li ZengDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.ORCID https://orcid.org/0000-0001-6232-0120
Rong HanShanghai University of Traditional Chinese Medicine, Shanghai 201210, China.ORCID https://orcid.org/0000-0001-9282-0222
Xiao-Qing DongShanghai University of Traditional Chinese Medicine, Shanghai 201210, China.ORCID https://orcid.org/0000-0002-6939-6010
Xiao-Cong GuoShanghai University of Traditional Chinese Medicine, Shanghai 201210, China.ORCID https://orcid.org/0000-0003-1288-8783
Zheng ShiShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0003-4144-6204
Guang YangShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-9739-6106
Yan-Ting YangShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0003-1388-4047
Dan ZhangShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0003-0747-8691
Xing-Tao ZhouDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.ORCID https://orcid.org/0000-0002-3465-1579
Xiao-Peng MaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-9532-4870
Shanghai Research Center for Acupuncture and Meridians · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUse of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children.

methodsA total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months.

resultsThe adjusted mean SE change over the 6 months was -0.38 ± 0.04 D in the 0.01% A group (

conclusionsAdjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.

Identifiers

PMID34422405
PMCPMC8373503
OpenAlexW3192009930

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.