Evidence map›Paper›PMID 34422351›Full record

ArticleJournal of thoracic disease2021

A retrospective observational study of benign anthracotic lymphadenitis and its association with PET avid lymph nodes in patients undergoing cancer evaluation.

Nathaniel M Ivanick, Pavan Shrestha, Michael J Podolsky, Vighnesh Walavalkar, Calixto-Hope Lucas, Yaron B Gesthalter, Eric J Seeley

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nathaniel M IvanickDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA.
Pavan ShresthaDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA.
Michael J PodolskyDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA.
Vighnesh WalavalkarDepartment of Pathology, University of California, San Francisco, CA, USA.
Calixto-Hope LucasDepartment of Pathology, University of California, San Francisco, CA, USA.
Yaron B GesthalterDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA.
Eric J SeeleyDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USRoswell Park Comprehensive Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate staging of newly diagnosed or recurrent malignancy is essential for effective treatment. An important first step in staging involves the use of PET/CT to identify areas of FDG avidity. PET/CT however has limitations, including false positive FDG uptake from benign causes. In this paper we characterize an uncommon yet clinically important cause of false positive PET/CTs, that of benign anthracotic lymphadenitis (BAL). We examine the clinical, radiographic and histologic characteristics of BAL in patients referred for endobronchial ultrasound (EBUS) guided biopsies and discuss its context in relation to existing literature.

methodsWe performed a retrospective observational case series of 20 patients who were referred for EBUS guided biopsies of PET positive mediastinal and hilar lymph nodes during the work-up or treatment of suspected malignancy.

resultsTo be included, all patients received PET imaging as well as an EBUS guided biopsy of FDG avid lymph nodes which demonstrated anthracotic pigment as the only histologic abnormality. The key findings were that 90% of patients in this cohort were born outside of the US, 90% had bilateral FDG avid lymph nodes with an average standardized uptake value (SUV) of 7.9±2.2. Most patients, based on their history, had a likely exposure to biomass fuel or urban pollution.

conclusionsBAL may be an underrecognized cause for PET positive lymph nodes in patients undergoing work-up for malignancy. These findings support the importance of sampling mediastinal and hilar lymph nodes even when SUVs are highly suggestive of malignancy.

Indexed as

Anthracosisendobronchial ultrasound (EBUS)mediastinal lymphadenopathynon-small cell lung cancer (NSCLC)PET/CT fusion imagingPET scan

Identifiers

PMID34422351
PMCPMC8339750
OpenAlexW3179350174

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.