Evidence map›Paper›PMID 34422272›Full record

ArticleSAGE open medicine2021

Inpatient glycemic control and outcome of COVID-19 patients: A retrospective cohort.

Christopher Lesniak, Raquel Ong, Monika S Akula, Steven Douedi, Arda Akoluk, Rabail Soomro, Albino Copca-Alvarez, Tiffany Purewal, Ishan Patel, Vandan Upadhyaya and 5 more

Open access · goldAbstract read
In one paragraph

Article in SAGE open medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Mean Blood Glucose Level During ICU Hospitalization is a Strong Predictor of the Mortality of COVID-19.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  3. Article
  4. Review
  5. The burden and risks of emerging complications of diabetes mellitus.Nature reviews. Endocrinology · 2022 · on this map
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Christopher LesniakDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.ORCID https://orcid.org/0000-0002-2614-9431
Raquel OngDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Monika S AkulaDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Steven DouediDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Arda AkolukDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Rabail SoomroDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Albino Copca-AlvarezDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Tiffany PurewalDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Ishan PatelDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Vandan UpadhyayaDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Jennifer ChengDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Ashali JainDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Arif AsifDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Krishna ChalasaniDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Mohammad A HossainDepartment of Medicine, Jersey Shore University Medical Center, Hackensack Meridian School of Medicine, Hackensack Meridian Health, Neptune, NJ, USA.
Hackensack Meridian Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAlthough there have been associations between diabetes and mortality in COVID-19 patients, it is unclear whether this is driven by the disease itself or whether it can be attributed to an inability to exhibit effective glucose control.

methodsWe conducted a retrospective cohort study of 292 patients admitted to a tertiary referral center to assess the association of mortality and glycemic control among COVID-19-positive patients. We used a logistic regression model to determine whether average fasting glycemic levels were associated with in-hospital mortality.

resultsAmong the diabetic and non-diabetic patients, there were no differences between mortality or length of stay. Mean glucose levels in the first 10 days of admission were higher on average among those who died (150-185 mg/dL) compared with those who survived (125-165 mg/dL). When controlling for multiple variables, there was a significant association between mean fasting glucose and mortality (odds ratio = 1.014, p < 0.001). The associations between glucose and mortality remained when controlled for comorbidities and glucocorticoid use.

conclusionThe results of this retrospective study show an association between mortality and inpatient glucose levels, suggesting that there may be some benefit to tighter glucose control in patients diagnosed with COVID-19.

Indexed as

blood glucoseCOVIDdiabetesmortality

Identifiers

PMID34422272
PMCPMC8375327
OpenAlexW3195281538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.