ReviewCirculation. Heart failure2021
Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop.
Erratum issuedOpen access · greenAbstract readReview
In one paragraph
Review in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Repurposing Heart Failure Therapies in Pulmonary Arterial Hypertension: Mechanistic Rationale, Translational Evidence, and Clinical Perspectives for SGLT2 Inhibitors and Mineralocorticoid Receptor Antagonists.Medicina (Kaunas, Lithuania) · 2026Review
- Assessment of Right Ventricular Adaptability to Pressure Overloading for Critical Therapeutic Decision-Making Processes.Journal of clinical medicine · 2026Review
- Consequences of Right Heart Disease for Cardiac Electrophysiology and Arrhythmias: Cellular and Structural Mechanisms.CJC open · 2025Review
- Incidence of Right Ventricular Dysfunction in an Echocardiographic Referral Cohort.Journal of the American Heart Association · 2025Article
- Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease from the PVDOMICS Study.Circulation. Cardiovascular imaging · 2024Observational
- Pathophysiology of the right ventricle and its pulmonary vascular interaction.The European respiratory journal · 2024Review
- Prognostic Significance of Proteomics-Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2024Article
- Insights Into Differences in Pulmonary Hemodynamics in Hispanic Patients With Pulmonary Arterial Hypertension.Cardiology research · 2024Article
- Approach to Decompensated Right Heart Failure in the Acute Setting.Journal of clinical medicine · 2024Review
- Venopulmonary extracorporeal membrane oxygenation for right ventricular support as a bridge to lung transplantation: A narrative review.SAGE open medicine · 2024Review
- Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension.Circulation. Heart failure · 2023Article
- Right ventricular function across the spectrum of health and disease.Heart (British Cardiac Society) · 2023Review
- A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- Extrapulmonary manifestations of pulmonary arterial hypertension.Expert review of respiratory medicineReview
Corrections and comments
- Erratum issued
Authors and funding
30 authors at 20 institutions in 3 countries.
Jane A Leopold *Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Steven M Kawut *Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Micheala A AldredDivision of Pulmonary, Critical Care, Sleep & Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN.
Stephen L ArcherDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Ray L BenzaDepartment of Medicine, Allegheny General Hospital, Pittsburgh, PA.
Michael R BristowDepartment of Medicine, University of Colorado, Denver, CO.
Evan L BrittainDivision of Cardiovascular Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN.
Naomi CheslerDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI.
Frances S DeManDepartment of Pulmonary Medicine, PHEniX laboratory, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Serpil C ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, OH.
Mark T GladwinDepartment of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, PA.
Paul M HassounDepartment of Medicine, Johns Hopkins University, Baltimore, MD.
Anna R HemnesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Tim LahmDivision of Pulmonary, Critical Care, Sleep & Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN.
Joao A C LimaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Joseph LoscalzoDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Bradley A MaronDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School and Department of Cardiology, Boston VA Healthcare System, West Roxbury, MA.
Laura Mercer RosaDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
John H NewmanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Susan RedlineDepartments of Medicine and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Stuart RichDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Franz RischardDepartment of Medicine, University of Arizona- Tucson, Tucson, AZ.
Lissa SugengDepartment of Medicine, Yale School of Medicine, New Haven, CT.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH.
Ryan J TedfordDivision of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC.
Emily J TsaiDivision of Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.
Corey E VentetuoloDepartment of Medicine, Alpert Medical School of Brown University, Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, RI.
YouYang ZhouDepartments of Pediatrics (Division of Critical Care), Pharmacology, and Medicine, Northwestern University Feinberg School of Medicine. Chicago, Illinois.
Neil R AggarwalDivision of Lung Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Lei XiaoDivision of Lung Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Vanderbilt University Medical Center · USBrigham and Women's Hospital · USIndiana University – Purdue University Indianapolis · USNational Heart Lung and Blood Institute · USNorthwestern University · USUniversity of Colorado Denver · USUniversity of Pennsylvania · USAllegheny General Hospital · USBrown University · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USColumbia College · CAJohns Hopkins University · USMedical University of South Carolina · USQueen's University · CAUniversity of Arizona · USUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · USVA Boston Healthcare System · USVrije Universiteit Amsterdam · NL
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MNITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3MGenomics of Pulmonary Vascular DiseaseR35HL140019 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ALDRED, MICHEALA A · 2018 to 2024
$5.6MAnastrozole in Pulmonary Arterial Hypertension (AIPH2) - CCC (Lead)R01HL134905 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2017 to 2021
$5.5MEffects of DHEA in Pulmonary Hypertension (DiPH)R01HL141268 · NHLBI · RHODE ISLAND HOSPITAL · PI VENTETUOLO, COREY E · 2018 to 2022
$3.7MNovel mechanisms of endothelial Injury in the pathogenesis of ARDSR01HL148810 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ZHAO, YOU-YANG · 2020 to 2023
$2.3MTargeting Smooth Muscle Progenitor Cells for Treatment of Pulmonary Arterial HypertensionR01HL140409 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ZHAO, YOU-YANG · 2018 to 2021
$2.0MIntergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7MMentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6MBLRD VA I01 BX002042NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K24 HL103844NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R01 HL134905NHLBI NIH HHS R01 HL140409NHLBI NIH HHS R01 HL141268NHLBI NIH HHS R01 HL148810NHLBI NIH HHS R35 HL135818NHLBI NIH HHS R35 HL140019NHLBI NIH HHS U01 HL125215
Abstract
Right ventricular dysfunction is a hallmark of advanced pulmonary vascular, lung parenchymal, and left heart disease, yet the underlying mechanisms that govern (mal)adaptation remain incompletely characterized. Owing to the knowledge gaps in our understanding of the right ventricle (RV) in health and disease, the National Heart, Lung, and Blood Institute (NHLBI) commissioned a working group to identify current challenges in the field. These included a need to define and standardize normal RV structure and function in populations; access to RV tissue for research purposes and the development of complex experimental platforms that recapitulate the
Indexed as
Heart FailureHumansHypertension, PulmonaryNational Heart, Lung, and Blood Institute (U.S.)Pulmonary CirculationUnited StatesVentricular Dysfunction, RightVentricular Function, Right
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.