Evidence map›Paper›PMID 34422131›Full record

ArticleNuclear medicine and molecular imaging2021

Mismatched Imaging Findings of Prostate Cancer Diagnosis: 68 Ga-PSMA PET/CT vs mpMRI.

Egesta Lopci, Piergiuseppe Colombo, Massimo Lazzeri

Registry-linked trialAbstract read
In one paragraph

Article in Nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05297162 (Diagnostic Performance and Clinical Impact of PSMA PET/CT vs. mpMRI in Patients With a High Suspicion of Prostate Cancer and Previously Negative Biopsy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05297162 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Diagnostic Performance and Clinical Impact of PSMA PET/CT vs. mpMRI in Patients With a High Suspicion of Prostate Cancer and Previously Negative Biopsy: a Head to Head, Parallel, Prospective Trial (PROSPET-BX)."

TypeinterventionalSponsorIstituto Clinico HumanitasRan2022 to 2025Enrolled128ConditionsProstate CancerArmsPSMA PET/TRUS (trans-rectal or trans-perineal) fusion biopsy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Egesta LopciNuclear Medicine Unit, IRCCS - Humanitas Research Hospital, Via Manzoni 56, CAP 20089 Rozzano, MI Italy.ORCID 0000-0001-9732-1094
Piergiuseppe ColomboPathology, IRCCS - Humanitas Research Hospital, Rozzano, MI Italy.
Massimo LazzeriUrology, IRCCS - Humanitas Research Hospital, Rozzano, MI Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiparametric magnetic resonance imaging (mpMRI) is the modality of choice for initial diagnosis of prostate cancer (PCa), including biopsy-naïve patients. Nevertheless, clinicians must be aware of the possibility that up to one-fourth of clinically significant cancers might be missed by the modality. Acknowledgment of this occurrence and the increased availability of 68 Ga-PSMA PET/CT in clinical routine, open the door to new, fascinating, indications for this functional modality in the context of PCa detection. With the case herein illustrated, we report a paradigmatic example of mismatch findings between PET/CT and mpMRI better elucidating the potential indication.

Indexed as

68 Ga-PSMA PET/CTFusion biopsyMpMRIPrimary diagnosisProstate cancer

Identifiers

PMID34422131
PMCPMC8322193

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.