ReviewJournal of the Intensive Care Society2021
Human albumin solutions in intensive care: A review.
Review in Journal of the Intensive Care Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Evaluation of albumin utilization, guideline compliance, and cost in intensive care units: a multicenter point prevalence study.BMC health services research · 2026Observational
- Development of a Prediction Model for Postoperative Hypoproteinemia in Patients Undergoing Microsurgical Reconstructive Surgery: A Prospective Observational Study.Nursing open · 2026Observational
- Complex Investigation of the Similarities and Differences between Ten Commercially Available Human Serum Albumin Preparations.ACS omega · 2025Article
- ICU readmission and mortality risk prediction: Generalizability of a multi-hospital model.Journal of intensive medicine · 2025Article
- The Efficacy of Albumin Infusion in Septic Patients with Hypoalbuminemia: An International Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations.Critical care (London, England) · 2025Observational
- Association between lactate-to-albumin ratio and 28-days all-cause mortality in patients with sepsis-associated liver injury: a retrospective cohort study.BMC infectious diseases · 2024Article
- Use of a Novel Buffered Hypertonic Saline Solution for Fluid Replacement and Resuscitation During Spinal Surgery in Adolescents.Journal of clinical medicine research · 2024Article
- From conflict to controversy: the use and abuse of human albumin solutions after the Second World War.Anaesthesia and intensive care · 2023Review
- Serum Albumin in Health and Disease: From Comparative Biochemistry to Translational Medicine.International journal of molecular sciences · 2023Article
- Expert perspectives for the pharmacist on facilitating and improving the use of albumin in cirrhosis.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023Review
- Peptide derivedHeliyon · 2023Article
- Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences.International journal of molecular sciences · 2022Article
- Comprehensive Investigations of Multiple Factors That Are Related to Refractory Outcome in Urosepsis Patients.Yonago acta medica · 2022Article
- Article
- Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties.International journal of molecular sciences · 2021Review
- Plasma as a resuscitation fluid for volume-depleted shock: Potential benefits and risks.Transfusion · 2021Review
- Hypoalbuminemia as Surrogate and Culprit of Infections.International journal of molecular sciences · 2021Review
- Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects.Journal of evolutionary biochemistry and physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Albumin plays a key role in the critically ill patient acting as a prognostic marker and as a therapy in the form of human albumin solutions. However, the use of human albumin solution has varied over time with notable differences between health systems. Whilst its use is widely accepted for some clinical indications, its role has not always been clear in the critically ill and has been found to be harmful in some cohorts. Numerous studies have showed conflicting results and critical care clinicians have not always been guided by robust evidence. Nonetheless, at present the use of human albumin solution appears to be increasing again in the United Kingdom. Below, we discuss the latest evidence base for its use in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.