Evidence map›Paper›PMID 34422094›Full record

ArticleComputational and mathematical methods in medicine2021

Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway.

Renjun Gao, Hongye Zhao, Xianyan Wang, Bo Tang, Yu Cai, Xinrui Zhang, Hao Zong, Yitong Li, Yanli Wang

Abstract read
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. SCAI Expert Consensus Statement on the Management of Patients With STEMI Referred for Primary PCI.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renjun GaoThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Hongye ZhaoDepartment of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Xianyan WangDepartment of Pathology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Bo TangThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yu CaiThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Xinrui ZhangThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Hao ZongThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yitong LiThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yanli WangThe Sixth Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.ORCID https://orcid.org/0000-0001-5661-4288

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the protective effects and mechanism of mild hypothermia treatment in the treatment of myocardial ischemia-reperfusion injury.

resultsThe expression of serum IL-6 and TNF-

conclusionIn conclusion, mild hypothermia therapy can inhibit the apoptosis and myocardial inflammation of cells induced by MI/R injury in rats and inhibiting the activity of the NLRP3 inflammasome pathway and p53 signaling pathway may be the mechanism.

Indexed as

AnimalsApoptosisCell LineComputational BiologyHypothermia, InducedInflammasomesInterleukin-6In Vitro TechniquesMyocardial Reperfusion InjuryMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinRatsRats, Sprague-DawleySignal TransductionTumor Necrosis Factor-alphaIl6 protein, ratInflammasomesInterleukin-6NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratTumor Necrosis Factor-alpha

Identifiers

PMID34422094
PMCPMC8371626

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.