ArticleFrontiers in plant science2021
Identification and Characterization of a Trillin Rhamnosyltransferase From
Article in Frontiers in plant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Identification and engineering of a UDP-rhamnosyltransferase fromBiodesign research · 2025Article
- The biosynthesis of trillin 6'-Synthetic and systems biotechnology · 2025Article
- An HD-ZIP I Transcription Factor DZHDZ32 Upregulates Diosgenin Biosynthesis inInternational journal of molecular sciences · 2025Article
- Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification.Cell death & disease · 2024Article
- Integrative analysis of metabolome and transcriptome provides new insights into functional components ofChinese herbal medicines · 2024Article
- Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth.Plant cell reports · 2024Article
- Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plantActa pharmaceutica Sinica. B · 2023Article
- Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae.Communications biology · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dioscorea zingiberensis accumulates abundant steroidal saponins, such as dioscin, which is the principal bioactive ingredient displaying a wide range of pharmacological activities. Diosgenin is the aglycone of dioscin, and recently, genes encoding cytochrome P450 enzymes in the late steps of diosgenin biosynthesis have been isolated. Diosgenin was successfully synthesized in the cholesterol-producing yeasts. From diosgenin to dioscin, one glucose and two rhamnose groups need to be added. Although genes encoding UDP-glucosyltransferases converting diosgenin to trillin were isolated, genes encoding UDP-rhamnosyltransferases involved in dioscin biosynthesis remain unknown. In this study, we isolated the cDNA encoding the trillin rhamnosyltransferase (designated DzGT1) from
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