Evidence map›Paper›PMID 34421861›Full record

ArticleFrontiers in microbiology2021

A New High-Throughput-Screening-Assay for Photoantimicrobials Based on EUCAST Revealed Unknown Photoantimicrobials in Cortinariaceae.

Johannes Fiala, Harald Schöbel, Pamela Vrabl, Dorothea Dietrich, Fabian Hammerle, Desirée Josefine Artmann, Ronald Stärz, Ursula Peintner, Bianka Siewert

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Revised taxon definition in EuropeanMycological progress · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Optimized isolation of 7,7'-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johannes FialaDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Harald SchöbelMCI - The Entrepreneurial School, Innsbruck, Austria.
Pamela VrablInstitute of Microbiology, University of Innsbruck, Innsbruck, Austria.
Dorothea DietrichInstitute of Microbiology, University of Innsbruck, Innsbruck, Austria.
Fabian HammerleDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Desirée Josefine ArtmannInstitute of Microbiology, University of Innsbruck, Innsbruck, Austria.
Ronald StärzMCI - The Entrepreneurial School, Innsbruck, Austria.
Ursula PeintnerInstitute of Microbiology, University of Innsbruck, Innsbruck, Austria.
Bianka SiewertDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Funding

Austrian Science Fund FWF P 31950Austrian Science Fund FWF T 862
6 · The paper itself

Abstract

Antimicrobial resistance is one of the biggest health and subsequent economic threat humanity faces. Next to massive global awareness campaigns, governments and NGOs alike stress the need for new innovative strategies to treat microbial infections. One of such innovative strategies is the photodynamic antimicrobial chemotherapy (PACT) in which the synergistic effects of photons and drugs are exploited. While many promising reports are available, PACT - and especially the drug-design part behind - is still in its infancy. Common best-practice rules, such as the EUCAST or CLSI protocols for classic antibiotics as well as high-throughput screenings, are missing, and this, in turn, hampers the identification of hit structures. Hit-like structures might come from synthetic approaches or from natural sources. They are identified via activity-guided synthesis or isolation strategies. As source for new antimicrobials, fungi are highly ranked. They share the same ecological niche with many other microbes and consequently established chemical strategies to combat with the others. Recently, in members of the Cortinariaceae, especially of the subgenus

Indexed as

anthraquinoneCortinariaceaeEUCASTLED-techniquePACTphotoantimicrobials

Identifiers

PMID34421861
PMCPMC8375034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.