Evidence map›Paper›PMID 34421847›Full record

ArticleFrontiers in microbiology2021

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in

Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 62 citations in OpenAlex.

  1. Targeting Outer Membrane Vesicles ofJournal of microbiology and biotechnology · 2026
    Review
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  4. Eco-friendly nanoparticles fromNanoscale advances · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Multidrug-resistantVirulence · 2025
    Review
  9. Article
  10. Article
  11. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. The role of cyano-phycocyanin as a quorum sensing inhibitor to attenuateFrontiers in cellular and infection microbiology · 2025
    Article
  18. Article
  19. Article
  20. Biofilm · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Dan YangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Suqi HaoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Ling ZhaoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Fei ShiCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Gang YeCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Yuanfeng ZouCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xu SongCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Lixia LiCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Zhongqiong YinCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xiaoli HeCollege of Science, Sichuan Agricultural University, Chengdu, China.
Shiling FengCollege of Life Science, Sichuan Agricultural University, Yaan, China.
Helin ChenCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Yu ZhangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Yuanze GaoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Yinglun LiCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Huaqiao TangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the prevalence of multidrug-resistant bacteria and clinical -acquired pathogenic infections, the development of quorum-sensing (QS) interfering agents is one of the most potential strategies to combat bacterial infections and antibiotic resistance. Chinese herbal medicines constitute a valuable bank of resources for the identification of QS inhibitors. Accordingly, in this research, some compounds were tested for QS inhibition using indicator strains. Paeonol is a phenolic compound, which can effectively reduce the production of violacein without affecting its growth in

Indexed as

anti-virulencebiofilmpaeonolPseudomonas aeruginosaquorum sensing

Identifiers

PMID34421847
PMCPMC8371487
OpenAlexW3187644879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.