ArticleFrontiers in endocrinology2021
Combination Usage of AdipoCount and Image-Pro Plus/ImageJ Software for Quantification of Adipocyte Sizes.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
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- High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images.Adipocyte · 2025Article
- Identification of genes related to the effects of bicalutamide and zoladex on benign prostatic hyperplasia.Scientific reports · 2025Article
- Inhibition of DPP-4 Attenuates Endotoxemia-Induced NLRC4 Inflammasome and Inflammation in Visceral Adipose Tissue of Mice Fed a High-Fat Diet.Biomolecules · 2025Article
- Unilocular adipocyte and lipid tracer for immunofluorescent images.Scientific reports · 2025Article
- Shift from visceral to subcutaneous adipose tissue in Cyp17a1-knockout rats prevents the progression of metabolic syndrome.PloS one · 2025Article
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- An automated in vitro wound healing microscopy image analysis approach utilizing U-net-based deep learning methodology.BMC medical imaging · 2024Article
- Study of association between corneal shape parameters and axial length elongation during orthokeratology using image-pro plus software.BMC ophthalmology · 2024Article
- Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy.Cell death & disease · 2023Article
- AAV-Mediated nuclear localized PGC1α4 delivery in muscle ameliorates sarcopenia and aging-associated metabolic dysfunctions.Aging cell · 2023Article
- Lupenone-Rich Fraction Derived fromLife (Basel, Switzerland) · 2023Article
- Irisin ameliorates age-associated sarcopenia and metabolic dysfunction.Journal of cachexia, sarcopenia and muscle · 2023Article
- Transport Stress Induces Oxidative Stress and Immune Response in Juvenile Largemouth Bass (Antioxidants (Basel, Switzerland) · 2023Article
- Article
- AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro.Molecular biology of the cell · 2022Article
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18 authors.
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Abstract
In recent decades, the prevalence of obesity has been rising. One of the major characteristics of obesity is fat accumulation, including hyperplasia (increase in number) and hypertrophy (increase in size). After histological staining, it is critical to accurately measure the number and size of adipocytes for assessing the severity of obesity in a timely fashion. Manual measurement is accurate but time-consuming. Although commercially available adipocyte counting tools, including AdipoCount, Image-Pro Plus, and ImageJ were helpful, limitations still exist in accuracy and time consuming. In the present study, we introduced the protocol of combined usage of these tools and illustrated the process with histological staining slides from adipose tissues of lean and obese mice. We found that the adipocyte sizes quantified by the tool combination were comparable as manual measurement, whereas the combined methods were more efficient. Besides, the recognition effect of monochrome segmentation image is better than that of color segmentation image. Overall, we developed a combination method to measure adipocyte sizes accurately and efficiently, which may be helpful for experimental process in laboratory and also for clinic diagnosis.
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