Evidence map›Paper›PMID 34421794›Full record

ArticleFrontiers in neurology2021

Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy.

Renato O Santos, Rodrigo Secolin, Patrícia G Barbalho, Mariana S Silva-Alves, Marina K M Alvim, Clarissa L Yasuda, Fábio Rogerio, Tonicarlo R Velasco, Americo C Sakamoto, Antonio L Teixeira and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Renato O SantosDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Rodrigo SecolinDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Patrícia G BarbalhoDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Mariana S Silva-AlvesDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Marina K M AlvimBrazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Clarissa L YasudaBrazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Fábio RogerioBrazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Tonicarlo R VelascoDepartment of Neuroscience and Behavioral Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Americo C SakamotoDepartment of Neuroscience and Behavioral Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Antonio L TeixeiraDepartment of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Fernando CendesBrazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.
Claudia V Maurer-MorelliDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Iscia Lopes-CendesDepartment of Translational Medicine, University of Campinas, Campinas, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the role of interleukin-1 beta (IL-1β) in the mechanisms underlying mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). We assessed a cohort of 194 patients with MTLE+HS and 199 healthy controls. Patients were divided into those with positive and negative antecedent febrile seizures (FS). We used a multidimensional approach, including (i) genetic association with single nucleotide polymorphisms (SNPs) in the

Indexed as

association studygene expressionhippocampal atrophymesial temporal sclerosisneuroinflammation

Identifiers

PMID34421794
PMCPMC8375265
OpenAlexW3192679652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.