Evidence map›Paper›PMID 34421705›Full record

ArticleFrontiers in psychology2021

Pathophysiology of Major Depression by Clinical Stages.

Ana Cecília de Menezes Galvão, Raíssa Nobrega Almeida, Geovan Menezes de Sousa, Mario André Leocadio-Miguel, Fernanda Palhano-Fontes, Dráulio Barros de Araujo, Bruno Lobão-Soares, João Paulo Maia-de-Oliveira, Emerson Arcoverde Nunes, Jaime Eduardo Cecilio Hallak and 3 more

Abstract read
In one paragraph

Article in Frontiers in psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cells · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana Cecília de Menezes GalvãoPostgraduate Program in Psychobiology, Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Raíssa Nobrega AlmeidaPostgraduate Program in Psychobiology, Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Geovan Menezes de SousaPostgraduate Program in Psychobiology, Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Mario André Leocadio-MiguelLaboratory of Neurobiology and Biological Rhythms, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Fernanda Palhano-FontesBrain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Dráulio Barros de AraujoBrain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Bruno Lobão-SoaresNational Institute of Science and Technology in Translational Medicine, São Paulo, Brazil.
João Paulo Maia-de-OliveiraNational Institute of Science and Technology in Translational Medicine, São Paulo, Brazil.
Emerson Arcoverde NunesNational Institute of Science and Technology in Translational Medicine, São Paulo, Brazil.
Jaime Eduardo Cecilio HallakNational Institute of Science and Technology in Translational Medicine, São Paulo, Brazil.
Felipe Barreto SchuchDepartment of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil.
Jerome SarrisNICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Nicole Leite Galvão-CoelhoPostgraduate Program in Psychobiology, Laboratory of Hormone Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (

Indexed as

brain-derived neurotrophic factorcortisolC-reactive proteinprecision psychiatrysleep quality

Identifiers

PMID34421705
PMCPMC8374436

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.