ArticleFrontiers in physiology2021
Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 3 citations in OpenAlex.
- DSA-NRP: No-Reflow Prediction From Angiographic Perfusion Dynamics in Stroke EVT.IEEE transactions on medical imaging · 2026Article
- Joint Temporal and Spectral Processing for Improved Digital Subtraction Angiography Using Photon-Counting Detectors.IEEE transactions on bio-medical engineering · 2025Article
- Computational fluid dynamics-based virtual angiograms for the detection of flow stagnation in intracranial aneurysms.International journal for numerical methods in biomedical engineering · 2023Article
- Sub-satisfactory recanalization of severe middle cerebral artery stenoses can significantly improve hemodynamics.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Digital subtraction angiography (DSA) is a fluoroscopic technique used extensively in interventional radiology for visualizing blood vessels. It has also been used to evaluate blood perfusion. However, the perfusion obtained in previous techniques was extracted from signal intensity rather than by the transport of contrast material (CM) through blood flow. The main aim of this study is to evaluate the morphological effects on the hemodynamics and the CM concentration in the middle cerebral artery (MCA) stenosis. We proposed a quantitative parameter, i.e., contrast material remaining time (CMRT), to describe the variation in the transport of CM over time. Computational fluid dynamics simulations were performed on both reconstructive synthetic and patient-derived models. In the synthetic models, we evaluated the variation of flow patterns and the transport of CM with different degrees of stenosis and the location of the lesion. It was found that an increase in the degree of stenosis (from 30 to 80%) resulted in a significant increase in CMRT at the anterior cerebral artery (ACA) outlet (
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