Evidence map›Paper›PMID 34421646›Full record

ArticleFrontiers in physiology2021

Transcriptional Time Course After Rotator Cuff Tear.

Laura S Vasquez-Bolanos, Michael C Gibbons, Severin Ruoss, Isabella T Wu, Mario Vargas-Vila, Sydnee A Hyman, Mary C Esparza, Donald C Fithian, John G Lane, Anshuman Singh and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Laura S Vasquez-BolanosDepartment of Bioengineering, University of California, San Diego, San Diego, CA, United States.
Michael C GibbonsDepartment of Bioengineering, University of California, San Diego, San Diego, CA, United States.
Severin RuossDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Isabella T WuDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Mario Vargas-VilaDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Sydnee A HymanDepartment of Bioengineering, University of California, San Diego, San Diego, CA, United States.
Mary C EsparzaDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Donald C FithianDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
John G LaneDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Anshuman SinghDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States.
Chanond A NasamranCenter for Computational Biology and Bioinformatics, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Kathleen M FischCenter for Computational Biology and Bioinformatics, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Samuel R WardDepartment of Bioengineering, University of California, San Diego, San Diego, CA, United States.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

Rotator cuff (RC) tears are prevalent in the population above the age of 60. The disease progression leads to muscle atrophy, fibrosis, and fatty infiltration in the chronic state, which is not improved with intervention or surgical repair. This highlights the need to better understand the underlying dysfunction in muscle after RC tendon tear. Contemporary studies aimed at understanding muscle pathobiology after RC tear have considered transcriptional data in mice, rats and sheep models at 2-3 time points (1 to 16 weeks post injury). However, none of these studies observed a transition or resurgence of gene expression after the initial acute time points. In this study, we collected rabbit supraspinatus muscle tissue with high temporal resolution (1, 2, 4, 8, and 16 weeks) post-tenotomy (

Indexed as

muscle atrophymuscle biologyrotator cuffrotator cuff muscle dysfunctiontenotomytime series data analysistranscriptome (RNA-seq)

Identifiers

PMID34421646
PMCPMC8378535

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.