Evidence map›Paper›PMID 34421639›Full record

ArticleFrontiers in physiology2021

Upregulation of miR181a/miR212 Improves Myogenic Commitment in Murine Fusion-Negative Rhabdomyosarcoma.

Enrico Pozzo, Nefele Giarratana, Gabriele Sassi, Merve Elmastas, Theo Killian, Chao-Chi Wang, Vittoria Marini, Flavio Ronzoni, Jason Yustein, Anne Uyttebroeck and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Enrico PozzoStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Nefele GiarratanaStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Gabriele SassiStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Merve ElmastasStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Theo KillianVIB KU Leuven Center for Cancer Biology, Leuven, Belgium.
Chao-Chi WangStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Vittoria MariniStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
Flavio RonzoniHuman Anatomy Unit, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Jason YusteinCancer and Hematology Center, Texas Children's Hospital, Houston, TX, United States.
Anne UyttebroeckLeuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Maurilio SampaolesiStem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
KU Leuven · BEUniversity of Pavia · ITBaylor College of Medicine · USVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusion-negative rhabdomyosarcoma (FN-RMS) is the most common soft tissue sarcoma of childhood arising from undifferentiated skeletal muscle cells from uncertain origin. Currently used therapies are poorly tumor-specific and fail to tackle the molecular machinery underlying the tumorigenicity and uncontrolled proliferation of FN-RMS. We and other groups recently found that microRNAs (miRNA) network contributes to myogenic epigenetic memory and can influence pluripotent stem cell commitments. Here, we used the previously identified promyogenic miRNAs and tailored it to the murine FN-RMS. Subsequently, we addressed the effects of miRNAs

Indexed as

microRNAmurine modelpediatric cancerpromyogenic cocktailpromyogenic signalingrhabdomyosarcomaskeletal muscle

Identifiers

PMID34421639
PMCPMC8378536
OpenAlexW3191536651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.