ArticleFrontiers in physiology2021
Left Atrial Hypertension, Electrical Conduction Slowing, and Mechanical Dysfunction - The Pathophysiological Triad in Atrial Fibrillation-Associated Atrial Cardiomyopathy.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The prognostic value of left atrial low-voltage areas in atrial fibrillation recurrence after pulmonary vein isolation: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- A novel signal distribution-based approach to characterize atrial cardiomyopathy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Amplified P-wave duration predicts incident atrial fibrillation in the general population: Results from the Hamburg City Health Study.Heart rhythm O2 · 2026Article
- Head-to-head comparison of non-invasive markers of atrial cardiomyopathy and their association with arrhythmia recurrence after atrial fibrillation ablation.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Association of non-invasive atrial cardiomyopathy markers with cerebral stroke lesions: a population-based analysis from the Hamburg City Health Study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Atrial Cardiomyopathy and Atrial Fibrillation in Different Heart Failure Substrates.Arrhythmia & electrophysiology review · 2026Review
- Atrial cardiomyopathy: From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the ESC.European journal of heart failure · 2025Article
- ECG-based identification of COPD patients at risk for atrial fibrillation and its impact on adverse clinical outcomes-a subgroup analysis of the prospective multicenter COSYCONET cohort.Respiratory research · 2025Article
- Observational
- Non-invasive prediction of atrial cardiomyopathy characterized by multipolar high-density contact mapping.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Left Atrial Cardiomyopathy: A Puzzling Disease Process Short of an Easy Answer.Journal of the American Heart Association · 2024Article
- Prognostic value of P-wave morphology in general population.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis.Journal of clinical medicine · 2022Article
- Sex differences in the association between blood pressure and atrial fibrillation: A case-control study.Frontiers in cardiovascular medicine · 2022Article
- Electro-characteristics of Myocardial Pouches and Reduction of the Frequency of Steam Pops During Radiofrequency Ablation.Frontiers in physiology · 2022Article
- Left Atrial Cardiomyopathy - A Challenging Diagnosis.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) is the most common arrhythmia and a significant burden for healthcare systems worldwide. Presence of relevant atrial cardiomyopathy (ACM) is related to persistent AF and increased arrhythmia recurrence rates after pulmonary vein isolation (PVI).
objectiveTo investigate the association of left atrial pressure (LAP), left atrial electrical [invasive atrial activation time (IAAT) and amplified p-wave duration (aPWD)] and mechanical [left atrial emptying fraction (LA-EF) and left atrial strain (LAS)] functional parameters with the extent of ACM and their impact on arrhythmia recurrence following PVI. MATERIALS AND
methodsFifty patients [age 67 (IQR: 61-75) years, 78% male] undergoing their first PVI for persistent AF were prospectively included. LAP (maximum amplitude of the v-wave), digital 12-lead electrocardiogram, echocardiography and high-density endocardial contact mapping were acquired in sinus rhythm prior to PVI. Arrhythmia recurrence was assessed using 72-hour Holter electrocardiogram at 6 and 12 months post PVI.
resultsRelevant ACM (defined as left atrial low-voltage extent ≥2 cm
conclusionLeft atrial hypertension, electrical conduction slowing and mechanical dysfunction are associated with ACM. These findings improve the understanding of ACM pathophysiology and may be suitable for risk stratification for new-onset AF, arrhythmia recurrence following PVI, and development of novel therapeutic strategies to prevent AF and its associated complications.
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