Evidence map›Paper›PMID 34421508›Full record

ArticleFrontiers in neuroscience2021

Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive/Compulsive Disorder Scores in Euthyroid Women.

Panagiota Konstantakou, Nikos Chalarakis, Georgios Valsamakis, Evangelos Grigoriou Sakkas, Eleni Vousoura, Alexandros Gryparis, Grigorios Evangelou Sakkas, George Papadimitriou, Ioannis Zervas, George Mastorakos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Thyroid functions in patients with hypochondriasis.Northern clinics of Istanbul · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Panagiota KonstantakouUnit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Nikos ChalarakisDepartment of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece.
Georgios ValsamakisUnit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Evangelos Grigoriou SakkasUnit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Eleni VousouraDepartment of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece.
Alexandros GryparisUnit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Grigorios Evangelou SakkasRea Maternity, Private Hospital, Athens, Greece.
George PapadimitriouDepartment of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece.
Ioannis ZervasDepartment of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece.
George MastorakosUnit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Eginition Hospital · GRNational and Kapodistrian University of Athens · GRLETO Maternity Hospital · GRAlexandra Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThyroid dysfunction (overt and subclinical) has been consistently linked to pregnancy adversity and abnormal fetal growth and development. Mood disorders such as anxiety, depression, and obsessive-compulsive disorder (OCD) are frequently diagnosed during pregnancy and at postpartum, and emerging evidence suggests association with impaired offspring neurodevelopment and growth. This study aimed to examine potential associations between thyroid function and mood symptoms during pregnancy and postpartum.

designThis is a prospective study measuring thyroid hormones and assessing mood symptoms by employing specific questionnaires in the same cohort of 93 healthy pregnant women at the 24th (2nd trimester) and 36th (3rd trimester) gestational weeks and at the 1st postpartum week.

methodsSerum thyroid hormones, TSH, anti-TPO, and anti-Tg antibodies were measured at the 24th (2nd trimester) and 36th (3rd trimester) gestational weeks and at the 1st postpartum week. Specific validated questionnaires were employed at the same time-points to assess separately symptoms of anxiety [Generalized Anxiety Disorder Inventory (GADI), Penn State Worry Questionnaire (PSWQ), STAI-State Anxiety inventory (STAI-S), STAI-Trait Anxiety Inventory (STAI-T)], depression [Edinburgh Postnatal Depression Scale (EPDS), Stein's Blues Scale (BLUES), Beck Depression Inventory (BDI)], and obsessive compulsive disorder (OCD) [Yale-Brown Obsessive Compulsive scale (Y-BOCS)].

resultsAt the 2nd trimester, GADI score correlated negatively with FT3 (

conclusionThe reported findings demonstrate positive associations between low-normal thyroid function at the 2nd and 3rd trimesters of pregnancy and postpartum with anxiety, depression, and OCD scores.

Indexed as

anxietydepressionobsessive—compulsive disorderpostpartumpregnancypsychometricsthyroid hormone

Identifiers

PMID34421508
PMCPMC8371251
OpenAlexW3190070425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.