Evidence map›Paper›PMID 34421499›Full record

ArticleMolecular syndromology2021

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Mara Dierssen, Yann Herault, Pablo Helguera, Maria Martínez de Lagran, Anna Vazquez, Bradley Christian, Maria Carmona-Iragui, Frances Wiseman, William Mobley, Elizabeth M C Fisher and 24 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular syndromology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 10 countries.

Mara DierssenCentre for Genomic Regulation, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Yann HeraultUniversité de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Pablo HelgueraInstituto Ferreyra, INIMEC-CONICET-UNC, Córdoba, Argentina.
Maria Martínez de LagranCentre for Genomic Regulation, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Anna VazquezUniversitat Pompeu Fabra (UPF), Barcelona, Spain.
Bradley ChristianWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Maria Carmona-IraguiSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Frances WisemanUK Dementia Research Institute, University College London, London, United Kingdom.
William MobleyUniversity of California-San Diego, San Diego, California, USA.
Elizabeth M C FisherUniversity College London, London, United Kingdom.
Veronique BraultUniversité de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Anna EsbensenUniversity of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lisa M JacolaSt Jude Children's Research Hospital, Memphis, Tennessee, USA.
Marie Claude PotierBrain & Spine Institute (ICM), CNRS UMR7225 - INSERM U1127 - UPMC Hôpital de la Pitié-Salpêtrière, Paris, France.
Eric D HamlettMedical University of South Carolina, Columbia, South Carolina, USA.
Leonard AbbedutoUniversity of California-Davis, Davis, California, USA.
Laura Del Hoyo SorianoUniversity of California-Davis, Davis, California, USA.
Jorge BusciglioUniversity of California-Irvine, Irvine, California, USA.
Maria Florencia IulitaMcGill University and Université de Montréal, Montréal, Québec, Canada.
John CrispinoNorthwestern University, Evanston, Illinois, USA.
Sébastien MalingeTelethon Kids Institute - Cancer Centre, Nedlands, Washington, Australia.
Eugenio BaroneSapienza University of Rome, Rome, Italy.
Marzia PerluigiSapienza University of Rome, Rome, Italy.
Floriana CostanzoBambino Gesù Children's Hospital, Rome, Italy.
Jean Maurice DelabarBrain & Spine Institute (ICM), CNRS UMR7225 - INSERM U1127 - UPMC Hôpital de la Pitié-Salpêtrière, Paris, France.
Renata BartesaghiUniversity of Bologna, Bologna, Italy.
Alain D DekkerUniversity of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Peter De DeynUniversity of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Juan Fortea OrmaecheaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Patricia A ShawBoston University, Boston, Massachusetts, USA.
Tarik F HaydarBoston University, Boston, Massachusetts, USA.
Stephanie L ShermanEmory University, Atlanta, Georgia, USA.
André StrydomKing's College London, London, United Kingdom.
Anita BhattacharyyaWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Centre National de la Recherche Scientifique · FRBoston University · USSapienza University of Rome · ITUniversitat Autònoma de Barcelona · ESUniversitat Pompeu Fabra · ESUniversity Medical Center Groningen · NLUniversity of California, Davis · USUniversity of Wisconsin–Madison · USBambino Gesù Children's Hospital · ITCentre for Biomedical Network Research on Rare Diseases · ESCincinnati Children's Hospital Medical Center · USConsejo Nacional de Investigaciones Científicas y Técnicas · AREmory University · USKing's College London · GBMcGill University · CAMedical University of South Carolina · USNorthwestern University · USSt. Jude Children's Research Hospital · USThe Kids Research Institute Australia · AUUK Dementia Research Institute · GB

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/S001298/1NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. The Third International Conference of T21RS, held June 6-9, 2019, in Barcelona, Spain, brought together 429 scientists, families, and industry representatives to share the latest discoveries on underlying cellular and molecular mechanisms of T21, define cognitive and behavioral challenges and better understand comorbidities associated with Down syndrome, including Alzheimer's disease and leukemia. Presentation of cutting-edge results in neuroscience, neurology, model systems, psychology, cancer, biomarkers and molecular and phar-ma-cological therapeutic approaches demonstrate the compelling interest and continuing advancement in all aspects of understanding and ameliorating conditions associated with T21.

Indexed as

Alzheimer's diseaseBiomarkersDown syndromeIntellectual disabilityLanguage impairmentMouse modelsNeurodevelopmental disordersTrisomy 21 Research Society

Identifiers

PMID34421499
PMCPMC8339505
OpenAlexW3165626456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.