ReviewPhytochemistry reviews : proceedings of the Phytochemical Society of Europe2022
A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes.
Review in Phytochemistry reviews : proceedings of the Phytochemical Society of Europe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 2 of them syntheses that pooled it.
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Who cites it
198 citing papers in PubMed, 2 syntheses or guidelines pooled it, 490 citations in OpenAlex.
- Pooled it
- Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Trial
- Effects of an Extract of the Brown SeaweedMarine drugs · 2023Trial
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- Bio-guided fractionation of (9Z )-5,8,11-trihydroxyoctadec-9-enoic acid from Abelmoschus sagittifolius root as a potent α-glucosidase inhibitor: An integrated in vitro and in silico study.Journal of the science of food and agriculture · 2026Article
- Vincoside Lactam from EdibleFoods (Basel, Switzerland) · 2026Article
- In Vitro Digestive-Enzyme Inhibition and Antiglycation Activity ofCurrent issues in molecular biology · 2026Article
- Chemometric insights into Lactiplantibacillus plantarum effects on onion (Allium cepa L.) metabolism and antidiabetic activity under cadmium stress.Scientific reports · 2026Article
- Ultrasound-assisted deep eutectic solvent extraction and macroporous resin enrichment of polyphenols from Cortex Mori: Screening of tyrosinase inhibitors via affinity ultrafiltration-LC-MS and molecular docking.Ultrasonics sonochemistry · 2026Article
- From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian Rhus coriaria L. Fruit.Chemistry & biodiversity · 2026Article
- Untargeted Metabolomic and Phytochemical Profiling ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Structural Characterization and Biological Evaluation of a Novel GlcNAc-Bearing Exopolysaccharide from the Mangrove Endophytic FungusMarine drugs · 2026Article
- Synthesis and Anti-Diabetic Evaluation of 2-Phenyl-3Pharmaceutics · 2026Article
- Novel 4-formyl-1,3-phenylene-bisoxy-bis(methylene)-bis(1,2,3-triazole-RSC advances · 2026Article
- Activity-Guided Isolation ofInternational journal of molecular sciences · 2026Article
- Phytochemical Characterization ofFood science & nutrition · 2026Article
- Phytochemical Characterization, In Vitro Antifungal and Antidiabetic Activities of Stem and Flower From Ethanol Extract of Hyptis capitata.Chemistry & biodiversity · 2026Article
- Design, Synthesis,Molecules (Basel, Switzerland) · 2026Article
- Structural Modifications of Hybrid O-Alkylsulfonyl-β-(Benzimidazol-1-yl)propioamidoximes as a Pathway to the Antimicrobial, Antifungal and Antidiabetic Drugs.International journal of molecular sciences · 2026Article
138 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information: The online version contains supplementary material available at 10.1007/s11101-021-09773-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.