Evidence map›Paper›PMID 34421329›Full record

ArticleMaterials today (Kidlington, England)

Flash Technology-Based Self-Assembly in Nanoformulation: From Fabrication to Biomedical Applications.

Hanze Hu, Chao Yang, Mingqiang Li, Dan Shao, Hai-Quan Mao, Kam W Leong

Abstract read
In one paragraph

Article in Materials today (Kidlington, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. A Versatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanze Hu *Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Chao Yang *Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Mingqiang LiLaboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China.
Dan ShaoInstitutes of Life Sciences, School of Biomedical Sciences and Engineering, Guangzhou International Campus, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510630, China.
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Funding

Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Engineering Polymers to Scavenge DAMPs in Arthritis and LupusR01AR073935 · NIAMS · DUKE UNIVERSITY · PI LEONG, KAM W, SULLENGER, BRUCE ALAN · 2018 to 2022
$3.3M
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative DisordersUG3NS115598 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2019 to 2021
$2.3M
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative DisordersUH3NS115598 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2022 to 2022
$1.6M
NCATS NIH HHS UH3 TR002151NIAMS NIH HHS R01 AR073935NINDS NIH HHS UG3 NS115598NINDS NIH HHS UH3 NS115598
6 · The paper itself

Abstract

Advances in nanoformulation have driven progress in biomedicine by producing nanoscale tools for biosensing, imaging, and drug delivery. Flash-based technology, the combination of rapid mixing technique with the self-assembly of macromolecules, is a new engine for the translational nanomedicine. Here, we review the state-of-the-art in flash-based self-assembly including theoretical and experimental principles, mixing device design, and applications. We highlight the fields of flash nanocomplexation (FNC) and flash nanoprecipitation (FNP), with an emphasis on biomedical applications of FNC, and discuss challenges and future directions for flash-based nanoformulation in biomedicine.

Indexed as

drug deliveryflash nanocomplexationflash nanoprecipitationnanoformulationself-assembly

Identifiers

PMID34421329
PMCPMC8375602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.