Evidence map›Paper›PMID 34421157›Full record

ArticleJournal of the American Statistical Association2021

Global and Simultaneous Hypothesis Testing for High-Dimensional Logistic Regression Models.

Rong Ma, T Tony Cai, Hongzhe Li

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. A Novel Approach of High Dimensional Linear Hypothesis Testing Problem.Journal of the American Statistical Association · 2025
    Article
  3. Debiased lasso after sample splitting for estimation and inference in high-dimensional generalized linear models.The Canadian journal of statistics = Revue canadienne de statistique · 2025
    Article
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  14. Inference for the Case Probability in High-dimensional Logistic Regression.Journal of machine learning research : JMLR · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rong MaUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 United States.
T Tony CaiUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 United States.
Hongzhe LiUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 United States.

Funding

Statistical Methods for Microbiome and MetagenomicsR01GM123056 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LEE, HONGZHE · 2017 to 2025
$3.7M
Methods for Integrative Genomic Data AnalysisR01GM129781 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Hongzhe Lee · 2018 to 2026
$3.5M
NIGMS NIH HHS R01 GM123056NIGMS NIH HHS R01 GM129781
6 · The paper itself

Abstract

High-dimensional logistic regression is widely used in analyzing data with binary outcomes. In this paper, global testing and large-scale multiple testing for the regression coefficients are considered in both single- and two-regression settings. A test statistic for testing the global null hypothesis is constructed using a generalized low-dimensional projection for bias correction and its asymptotic null distribution is derived. A lower bound for the global testing is established, which shows that the proposed test is asymptotically minimax optimal over some sparsity range. For testing the individual coefficients simultaneously, multiple testing procedures are proposed and shown to control the false discovery rate (FDR) and falsely discovered variables (FDV) asymptotically. Simulation studies are carried out to examine the numerical performance of the proposed tests and their superiority over existing methods. The testing procedures are also illustrated by analyzing a data set of a metabolomics study that investigates the association between fecal metabolites and pediatric Crohn's disease and the effects of treatment on such associations.

Indexed as

False discovery rateGlobal testingLarge-scale multiple testingMinimax lower bound

Identifiers

PMID34421157
PMCPMC8375316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.