Evidence map›Paper›PMID 34421137›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2021

Time-Resolved and Comprehensive Analysis of Surface Glycoproteins Reveals Distinct Responses of Monocytes and Macrophages to Bacterial Infection.

Suttipong Suttapitugsakul, Ming Tong, Ronghu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suttipong SuttapitugsakulSchool of Chemistry and Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Atlanta, GA 30332 (USA).
Ming TongSchool of Chemistry and Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Atlanta, GA 30332 (USA).
Ronghu WuSchool of Chemistry and Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Atlanta, GA 30332 (USA).ORCID 0000-0001-9493-9462

Funding

Supplemental Funds for a Thermo Scientific Q Exactive HF Mass SpectrometerR01GM127711 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WU, RONGHU · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM127711
6 · The paper itself

Abstract

Glycoproteins on the surface of immune cells play extremely important roles in response to pathogens. Yet, a systematic and time-resolved investigation of surface glycoproteins during the immune response remains to be explored. Integrating selective enrichment of surface glycoproteins with multiplexed proteomics, we globally and site-specifically quantified the dynamics of surface glycoproteins on THP-1 monocytes and macrophages in response to bacterial infection and during the monocyte-to-macrophage differentiation. The time-resolved analysis reveals transient changes and differential remodeling of surface glycoproteins on both cell types, and potential upstream regulators and downstream effects of the regulated glycoproteins. Besides, we identified novel surface glycoproteins participating in the immune response such as APMAP, and site-specific changes of glycoproteins. This study provides unprecedented information to deepen our understanding of glycoproteins and cellular activities.

Indexed as

glycoproteinsimmunologymembrane proteinsMS-based proteomicstime-resolved and comprehensive analysis

Identifiers

PMID34421137
PMCPMC8376197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.