SynthesisMedical science monitor : international medical journal of experimental and clinical research2021
Periodontitis and Number of Teeth in the Risk of Coronary Heart Disease: An Updated Meta-Analysis.
Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effects of Periodontal Therapy on Cardiovascular Risk Biomarkers: A Systematic Review.Oral health & preventive dentistry · 2025Pooled it
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Association between Dental and Cardiovascular Diseases: A Systematic Review.Reviews in cardiovascular medicine · 2023Pooled it
- Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease.Frontiers in bioengineering and biotechnology · 2023Pooled it
- The Association of Periodontitis With Cardiovascular Disease Parameters: A Synthesis of Systematic Reviews.International journal of dental hygiene · 2026Review
- Tooth Loss as a Predictor of Coronary Artery Disease Severity in Patients with Acute Myocardial Infarction: A Prospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications.Frontiers in immunology · 2026Review
- The systemic impact of periodontitis in about 100,000 patients: associations with heart diseases, cancer, and mortality.Clinical oral investigations · 2025Article
- Impact of Tooth Loss on Heart Failure After Myocardial Infarction: A Cross-Sectional Study Bridging Oral and Cardiovascular Health.Dentistry journal · 2025Article
- Tooth Loss and Cardiovascular Risk Burden in Myocardial Infarction Patients.Journal of clinical medicine · 2025Article
- Dental Disease as a Clinical Marker for Coronary Artery Disease Severity: A Narrative Review of Current Evidence and Mechanisms.Medicina (Kaunas, Lithuania) · 2025Review
- Severe Tooth Loss and Cardiovascular Disease Among Older Adults in Hawai'i: A Cross-Sectional Study of Behavioral Risk Factor Surveillance System Data from 2012 to 2020.Hawai'i journal of health & social welfare · 2025Article
- Impact of tooth loss and patient characteristics on coronary artery calcium score classification and prediction.Scientific reports · 2024Article
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- Maternal Salivary miR-423-5p Is Linked to Neonatal Outcomes and Periodontal Status in Cardiovascular-High-Risk Pregnancies.International journal of molecular sciences · 2024Article
- Salivary IL-1β, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity.International journal of molecular sciences · 2024Article
- Crosstalk between periodontitis and cardiovascular risk.Frontiers in immunology · 2024Review
- Role of circulating microparticles and cytokines in periodontitis associated with diabetes.Frontiers in medicine · 2024Article
- Secondary analysis of potential associations between oral health and infection-related parameters in patients with severe heart failure-results of a German cohort.BMC cardiovascular disorders · 2023Article
- A gender specific risk assessment of coronary heart disease based on physical examination data.NPJ digital medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND A positive link between periodontitis and chronic systemic disease has been indicated. However, few studies focused on the loss of teeth. Our analysis aims to analyze the relationship of periodontitis and number of teeth with the risk of coronary heart disease (CHD). MATERIAL AND METHODS A meta-analysis was conducted on qualified data extracted from the PubMed, Embase, and Cochrane Library databases. Only cohort studies were included in this study. We screened articles that assessed the periodontal condition and teeth number as well as the incidence or mortality of CHD. Hazard ratio (HR) and relative risk (RR) were calculated by Stata SE software. RESULTS A total of 11 prospective studies with over 200 000 total participants were analyzed. Ten studies reported on periodontitis and CHD, and 4 studies included data on number of teeth. After adjusting for multivariate factors, there was a significant association between periodontitis and the risk of CHD (RR, 1.18; 95% confidence interval [CI], 1.10-1.26); the RR of CHD in the edentulous population was 1.20 (95% CI, 1.08-1.34). Moreover, results on the RR values for number of teeth were as follows: 24-17 teeth (RR, 1.12; 95% CI, 1.05-1.19); 16-11 (RR, 1.28; 95% CI, 1.15-1.42); and £10 (RR, 1.55; 95% CI, 1.43-1.69). CONCLUSIONS Our study showed that periodontitis is a risk factor for CHD and that the number of removed teeth is positively correlated with the risk of CHD. During clinical assessment, both factors need to be considered as factors associated with cardiovascular risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.