Observational studyNeuroRehabilitation2021
Non-motor impairments affect walking kinematics in Parkinson disease patients: A cross-sectional study.
Observational study in NeuroRehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Evaluating the Relationship Between Early Non-Motor Symptoms and Late Diagnosis of Parkinson's Disease Based on the PPMI Database From 2012 to 2018: A Retrospective Cross-Sectional Study.Health science reports · 2026Article
- Impact of dual-tasking and balance confidence on turns and transitions: a cross-sectional study in Parkinson's disease.Scientific reports · 2026Article
- Assessment of reliability and concurrent validity of a single trunk-based IMU system to quantify spatiotemporal parameters in healthy individuals.BMC sports science, medicine & rehabilitation · 2025Article
- Evidence for the Link Between Non-Motor Symptoms, Kinematic Gait Parameters, and Physical Function in People with Parkinson's Disease.Bioengineering (Basel, Switzerland) · 2025Article
- Evaluation of walking activity and gait to identify physical and mental fatigue in neurodegenerative and immune disorders: preliminary insights from the IDEA-FAST feasibility study.Journal of neuroengineering and rehabilitation · 2024Article
- Bone involvement in the early stages of Parkinson's disease: a case-control study.The Journal of international medical research · 2024Article
- Factors Influencing Habitual Physical Activity in Parkinson's Disease: Considering the Psychosocial State and Wellbeing of People with Parkinson's and Their Carers.Sensors (Basel, Switzerland) · 2022Article
- Cognitive parameters can predict change of walking performance in advanced Parkinson's disease - Chances and limits of early rehabilitation.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with Parkinson disease (PD), severe postural and gait impairments are rarely observed in early stage of disease and non-motor symptoms (NMS) are often overlooked.
objectiveThis observational study aimed to characterize the impact of non-motor impairments on walking kinematics in early stages PD patients, and to assess the differences of gait parameters and NMS between PD patients with and without mild cognitive impairment (MCI).
methodsTwenty-six patients with Modified Hoehn and Yahr Scale score≤2 were evaluated for NMS using Kings Parkinson's Pain Scale, Parkinson Fatigue Severity scale, Parkinson Anxiety Scale, Beck Depression Inventory and Epworth Sleepiness Scale, kinematic parameters through an inertial sensor and cognitive performance by a comprehensive neuropsychological battery.
resultsFatigue had a moderate negative correlation with step cadence, and a moderate to strong positive correlation with gait duration, Timed Up and Go (TUG) and TUG Dual Task (p < 0.01). Pain showed positive moderate correlation with gait duration (p < 0.01). Twelve patients resulted affected by MCI and reported significantly worse scores in gait duration, pain and fatigue (p < 0.05). According to cognitive z scores, PD-MCI group showed a moderate negative correlation between visuospatial abilities and fatigue (p < 0.05).
conclusionsNMS significantly affect walking kinematics whereas a limited role of cognitive status on motor performance occur in the early PD stages.
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