ArticleJournal of Alzheimer's disease : JAD2021
Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07091643 (Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Depression and cognition: is there a bidirectional relationship?Aging & mental health · 2026Article
- Associations of Sleep Quality with Cognitive Function in Chinese Older Adults: The Roles of Self-Efficacy and Depressive Symptoms.Clinical interventions in aging · 2026Article
- An Introduction to Longitudinal Synthetic Cohorts for Studying the Life Course Drivers of Health Outcomes and Inequalities in Older Age.Current epidemiology reports · 2025Article
- Temporal Associations Between Cognitive Impairment and Depression in Older Adults: A Longitudinal Analysis.European journal of investigation in health, psychology and education · 2025Article
- Cognitive impairment in individuals with rheumatic diseases: the role of systemic inflammation, immunomodulatory medications, and comorbidities.The Lancet. Rheumatology · 2024Review
- Overcoming Data Gaps in Life Course Epidemiology by Matching Across Cohorts.Epidemiology (Cambridge, Mass.) · 2024Article
- Trajectories in depressive symptoms and midlife brain health.Translational psychiatry · 2024Article
- Association between pre-dementia psychiatric diagnoses and all-cause dementia is independent from polygenic dementia risks in the UK Biobank.EBioMedicine · 2024Article
- The Association of Cognitive Impairment With Depressive Symptoms, Function, and Pain in Hospitalized Older Patients With Dementia.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023Article
- Trauma and female reproductive health across the lifecourse: motivating a research agenda for the future of women's health.Human reproduction (Oxford, England) · 2023Review
- Direct and Indirect Effects of Socioeconomic Status and Discrimination on Subjective Cognitive Decline: A Longitudinal Study of African American Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Article
- Contribution of life course cardiovascular risk factors to racial disparities in dementia incidence.Frontiers in dementia · 2023Article
- Incidence of cognitive impairment after hypothetical interventions on depression, nighttime sleep duration, and leisure activity engagement among older Chinese adults: An application of the parametric g-formula.Frontiers in public health · 2023Article
- The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- The Relationship between Late-Life Depression and Cognitive Function in Older Korean Adults: A Moderation Analysis of Physical Activity Combined with Lower-Body Muscle Strength.International journal of environmental research and public health · 2022Article
- Sex Differences in the Association Between Midlife Cardiovascular Conditions or Risk Factors With Midlife Cognitive Decline.Neurology · 2022Article
- Fluctuation of depressive symptoms in cognitively unimpaired participants and the risk of mild cognitive impairment 5 years later: Results of the Heinz Nixdorf Recall study.Frontiers in behavioral neuroscience · 2022Article
- Speech markers of depression dimensions across cognitive status.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDepressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited.
objectiveTo impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and decline.
methodsUsing a pooled study of 4 prospective cohorts (ages 20-89), we imputed adult life course depressive symptoms trajectories based on Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and calculated time-weighted averages for early adulthood (ages 20-49), mid-life (ages 50-69), and late-life (ages 70-89) for 6,122 older participants. Adjusted pooled logistic and mixed-effects models estimated associations of imputed depressive symptoms with two cognitive outcomes: cognitive impairment defined by established criteria and a composite cognitive score.
resultsIn separate models, elevated depressive symptoms in each life stage were associated with cognitive outcomes: early adulthood OR for cognitive impairment = 1.59 (95%CI: 1.35,1.87); mid-life OR = 1.94 (95%CI:1.16, 3.26); and late-life OR = 1.77 (95%CI:1.42, 2.21). When adjusted for depressive symptoms in the other life-stages, elevated depressive symptoms in early adulthood (OR = 1.73; 95%CI: 1.42,2.11) and late-life (OR = 1.43; 95%CI: 1.08,1.89) remained associated with cognitive impairment and were also associated with faster rates of cognitive decline (p < 0.05).
conclusionImputing depressive symptom trajectories from pooled cohorts may help expand data across the life course. Our findings suggest early adulthood depressive symptoms may be a risk factor for cognitive impairment independent of mid- or late-life depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.