Evidence map›Paper›PMID 34420894›Full record

ReviewSeminars in fetal & neonatal medicine2021

Placental contribution to neonatal encephalopathy.

A A Penn, P Wintermark, L F Chalak, J Armstrong, R Redline, M S Scher, K B Nelson, Newborn Brain Society Guidelines and Publications Committee. Electronic address: http://publications@newbornbrainsociety.org

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Placental pathology in perinatal asphyxia: a case-control study.Frontiers in clinical diabetes and healthcare · 2023
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

A A PennDivision of Neonatology, Department of Pediatrics, Columbia University, New York, NY, USA. Electronic address: aap2216@columbia.edu.
P WintermarkDivision of Newborn Medicine, Montreal Children's Hospital, Montreal, Canada.
L F ChalakNeonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, Dallas, USA.
J ArmstrongDepartment of Pediatrics (Section of Child Neurology, Neurology, and OB/GYN), University of Colorado Anschutz Medical Campus, Hemophilia and Thrombosis Center, Aurora, CO, USA.
R RedlineDepartment of Pathology, UH Cleveland Medical Center, Cleveland, OH, USA.
M S ScherCase Western Reserve University School of Medicine, Department of Pediatrics, Department of Neurology, Rainbow Babies and Children's Hospital/MacDonald Hospital for Women, UH Cleveland Medical Center, Cleveland, OH, USA.
K B NelsonNational Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.
Newborn Brain Society Guidelines and Publications Committee. Electronic address: http://publications@newbornbrainsociety.org
Columbia University · USMontreal Children's Hospital · CANational Institute of Neurological Disorders and Stroke · USRainbow Babies & Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Novel Roles of Placental Allopregnanolone in Brain Development and InjuryR01HD092593 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANNA A PENN · 2017 to 2026
$3.9M
NICHD NIH HHS R01 HD092593
6 · The paper itself

Abstract

Placental assessment, although currently underused, can inform our understanding of the etiology and timing of Neonatal Encephalopathy (NE). We review our current understanding of the links between placental dysfunction and NE and how this information may inform clinical decisions, now and in the future, emphasizing the four major placental lesions associated with NE. In addition, we discuss maternal and fetal factors that are hypothesized to contribute to specific placental pathologies, especially innate or acquired thrombophilias. We outline the importance of assessing placenta across trimesters and after delivery. As this field continues to evolve, currently available placental histopathological examination methods may need to be combined with advanced prenatal molecular and imaging assessments of placenta and be applied in well-designed studies in large representative populations to better define the links between placental dysfunction and NE.

Indexed as

Brain DiseasesInfant, Newborn, DiseasesPlacenta DiseasesFemaleHumansInfant, NewbornPlacentaPregnancyPregnancy, High-RiskChorioamnionitisChronic villitisFetal vascular malperfusionHistopathologyMaternal vascular malperfusionNeonatal encephalopathyPerinatal brain injuryPlacentaVillitis of unknown etiology

Identifiers

PMID34420894
PMCPMC11912380
OpenAlexW3189881118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.