Evidence map›Paper›PMID 34420657›Full record

ArticleKidney international2021

Pumping iron in the kidney.

Allison L Fisher, Jodie L Babitt

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Allison L FisherDivision of Nephrology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jodie L BabittDivision of Nephrology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: Babitt.jodie@mgh.harvard.edu.

Funding

TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
Regulation of Iron Homeostasis by BMP SignalingR01DK087727 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L · 2010 to 2024
$6.0M
BMP Ligands in Hepcidin RegulationR01DK128068 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L, CHRISTIAN, JAN L · 2021 to 2024
$2.6M
NIDDK NIH HHS R01 DK087727NIDDK NIH HHS R01 DK128068NIDDK NIH HHS T32 DK007540
6 · The paper itself

Abstract

Iron balance is tightly controlled to provide adequate amounts of this essential nutrient, but to limit the adverse effects of excess iron. Key mediators of systemic iron homeostasis are the iron regulatory hormone hepcidin and its receptor, the iron export protein ferroportin. A new study by Mohammad et al. demonstrates the functional role of the hepcidin-ferroportin axis in the kidney, and how this contributes to kidney iron levels and the systemic iron economy.

Indexed as

IronIron OverloadHomeostasisHumansKidneyIron

Identifiers

PMID34420657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.