Evidence map›Paper›PMID 34420105›Full record

ArticleEJNMMI radiopharmacy and chemistry2021

One-pot and one-step automated radio-synthesis of [

Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05442151 (Evaluation Using FAPI-PET Targeting Cancer-associated Fibroblasts), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05442151 narecruitingnot on this mapstarted 2022, after this paper: background citation

Evaluation Using FAPI-PET Targeting Cancer-associated Fibroblasts

TypeinterventionalSponsorTadashi WatabeRan2022 to 2026Enrolled200ConditionsNeoplasmsArmsPET/CT ([F-18]FAPI-74)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Automated and manual synthesis of [EJNMMI radiopharmacy and chemistry · 2026
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  2. Combined antitumor activity of [EJNMMI research · 2026
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  3. cGMP-compliant high-yield automated production of [EJNMMI radiopharmacy and chemistry · 2025
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  4. Optimizing [EJNMMI research · 2025
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  5. Production and Quality Control of [Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Evaluation of Targeted Alpha Therapy Using [International journal of molecular sciences · 2024
    Article
  10. Article
  11. Impact ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Initial Evaluation of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Sadahiro NakaDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. naka@tracer.med.osaka-u.ac.jp.
Tadashi WatabeDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Thomas LindnerDepartment for Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Jens CardinaleDepartment of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.
Kenta KurimotoDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Melissa MooreSOFIE, 21000 Atlantic Boulevard Suite 730, Dulles, VA, 20166, USA.
Mitsuaki TatsumiDepartment of Radiology, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yuriko MoriDepartment of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.
Eku ShimosegawaDepartment of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Frank VallaDepartment of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.
Hiroki KatoDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Frederik L GieselDepartment for Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Osaka University · JPDüsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DEHeidelberg University · DEOsaka University Hospital · JPSofie Biosciences (United States) · US

Funding

QiSS program of OPERA from the Japan Science and Technology Agency Japan JPMJOP1721
6 · The paper itself

Abstract

backgroundFibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [

resultsRadiosynthesis of [

conclusionsWe established a one-pot one-step automated synthesis method using a CFN-MPS200 synthesizer that provided high radioactivity and stable radiochemical purity for possible clinical applications.

Indexed as

[18F]AlF-FAPI-74Automated synthesisFibroblast activation proteinPositron emission tomography

Identifiers

PMID34420105
PMCPMC8380200
OpenAlexW3194247059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.