ArticleNeuroImage2021
Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 90 citations in OpenAlex.
- Morphometric alterations of the gray matter of the frontal lobe during childhood in healthy children born prematurely. Repercussions of foetal and postnatal growth restriction.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Parietal thickness predicts middle temporal area (V5) motion responses in 7-year-old children born very preterm.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin.PLoS biology · 2026Article
- Hippocampal morphometry is altered in infants with congenital heart disease.Brain communications · 2026Article
- Summary of Best Evidence for the Management and Recurrence Prevention of Febrile Seizures in Children.Journal of multidisciplinary healthcare · 2026Review
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Neural and behavioural correlates of theory of mind reasoning in five-year-old children born preterm.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Cortical Morphology and Morphometric Similarity Network Topology Alterations in Preterm Neonates: Insights From an East Asian Cohort.Human brain mapping · 2025Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Revealing morphological fingerprints in perinatal brains using quasi-conformal mapping: occurrence and neurodevelopmental implications.Brain imaging and behavior · 2025Article
- Brain MRI before and at term equivalent age predicts motor and cognitive outcomes in very preterm infants.Neuroimage. Reports · 2025Article
- Differential patterns of cortical expansion in fetal and preterm brain development.bioRxiv : the preprint server for biology · 2025Article
- Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.The American journal of pathology · 2025Article
- Cortical scaling of the neonatal brain in typical and altered development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- Early Development and Co-Evolution of Microstructural and Functional Brain Connectomes: A Multi-Modal MRI Study in Preterm and Full-Term Infants.Human brain mapping · 2025Article
- Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study.BMC medical imaging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 7 institutions in 4 countries.
Funding
Abstract
introductionThe dynamic nature and complexity of the cellular events that take place during the last trimester of pregnancy make the developing cortex particularly vulnerable to perturbations. Abrupt interruption to normal gestation can lead to significant deviations to many of these processes, resulting in atypical trajectory of cortical maturation in preterm birth survivors.
methodsWe sought to first map typical cortical micro- and macrostructure development using invivo MRI in a large sample of healthy term-born infants scanned after birth (n = 259). Then we offer a comprehensive characterization of the cortical consequences of preterm birth in 76 preterm infants scanned at term-equivalent age (37-44 weeks postmenstrual age). We describe the group-average atypicality, the heterogeneity across individual preterm infants, and relate individual deviations from normative development to age at birth and neurodevelopment at 18 months.
resultsIn the term-born neonatal brain, we observed heterogeneous and regionally specific associations between age at scan and measures of cortical morphology and microstructure, including rapid surface expansion, greater cortical thickness, lower cortical anisotropy and higher neurite orientation dispersion. By term-equivalent age, preterm infants had on average increased cortical tissue water content and reduced neurite density index in the posterior parts of the cortex, and greater cortical thickness anteriorly compared to term-born infants. While individual preterm infants were more likely to show extreme deviations (over 3.1 standard deviations) from normative cortical maturation compared to term-born infants, these extreme deviations were highly variable and showed very little spatial overlap between individuals. Measures of regional cortical development were associated with age at birth, but not with neurodevelopment at 18 months.
conclusionWe showed that preterm birth alters cortical micro- and macrostructural maturation near the time of full-term birth. Deviations from normative development were highly variable between individual preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.