ArticleEnvironmental research2022
Child serum metabolome and traffic-related air pollution exposure in pregnancy.
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Untargeted serum metabolomics and air pollution in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
- Untargeted serum metabolomics and air pollution in Parkinson's disease.Research square · 2026Article
- Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Early-Life Air Pollution Exposure Is Associated with the Infant Gut Microbiome and Fecal Metabolome in the First Two Years of Life.Research report (Health Effects Institute) · 2026Article
- Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Prenatal Nitrogen Oxide (NOEnvironmental science & technology · 2025Article
- Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome.Environmental science & technology · 2025Article
- An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Dysregulated metabolic pathways associated with air pollution exposure and the risk of autism: Evidence from epidemiological studies.Environmental pollution (Barking, Essex : 1987) · 2024Review
- Prenatal and Early Life Exposure to Ambient Air Pollutants Is Associated with the Fecal Metabolome in the First Two Years of Life.Environmental science & technology · 2024Article
- Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study.Antioxidants (Basel, Switzerland) · 2023Article
- Exposome epidemiology for suspect environmental chemical exposures during pregnancy linked to subsequent breast cancer diagnosis.Environment international · 2023Article
- A State-of-the-Science Review on High-Resolution Metabolomics Application in Air Pollution Health Research: Current Progress, Analytical Challenges, and Recommendations for Future Direction.Environmental health perspectives · 2023Review
- Inflammation and the Potential Implication of Macrophage-Microglia Polarization in Human ASD: An Overview.International journal of molecular sciences · 2023Review
- Air pollution, metabolites and respiratory health across the life-course.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Article
- Common Fatal Neurodegenerative Diseases Revisited: Beyond Age, Comorbidities, and Devastating Terminal Neuropathology There Is Hope With Prevention.Frontiers in neurology · 2022Article
- Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.Environmental science & technology letters · 2021Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMaternal exposure to traffic-related air pollution during pregnancy has been shown to increase the risk of adverse birth outcomes and childhood disorders. High-resolution metabolomics (HRM) has previously been employed to identify metabolic responses to traffic-related air pollution in adults, including pregnant women. Thus far, no studies have examined metabolic effects of air pollution exposure in utero on neonates.
methodsWe retrieved stored neonatal blood spots for 241 children born in California between 1998 and 2007. These children were randomly selected from all California birth rolls to serve as birth-year matched controls for children with retinoblastoma identified from the California cancer registry for a case control study of childhood cancer. We estimated prenatal traffic-related air pollution exposure (particulate matter less than 2.5 μm (PM
resultsIn total we extracted 4038 and 4957 metabolite features from neonatal blood spots in hydrophilic interaction (HILIC) chromatography (positive ion mode) and C18 reverse phase columns (negative ion mode), respectively. After controlling for confounding factors, partial least square regression (Variable Importance in Projection (VIP) ≥ 2) selected 402 HILIC positive and 182 C18 negative features as statistically significantly associated with increasing third trimester PM
conclusionThe metabolite features and pathways associated with air pollution exposure in neonates suggest that maternal exposure during late pregnancy contributes to oxidative stress and inflammation in newborn children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.