Evidence map›Paper›PMID 34419404›Full record

ArticleJACC. Cardiovascular imaging2022

Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study.

Rebecca S Beroukhim, Sunil Ghelani, Ravi Ashwath, Sowmya Balasubramanian, David M Biko, Sujatha Buddhe, M Jay Campbell, Russell Cross, Pierluigi Festa, Lindsay Griffin and 26 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Foetal detection of a mitral leaflet mass.The international journal of cardiovascular imaging · 2026
    Article
  2. Article
  3. A rare pediatric cardiac papillary fibroelastoma: a case report.Frontiers in cardiovascular medicine · 2026
    Article
  4. Fetal cardiac masses.Pediatric radiology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Biomedical Applications of Gadolinium-Containing Biomaterials: Not Only MRI Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  11. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 6 countries.

Rebecca S BeroukhimBoston Children's Hospital, Boston, Massachusetts, USA. Electronic address: rebecca.beroukhim@cardio.chboston.org.
Sunil GhelaniBoston Children's Hospital, Boston, Massachusetts, USA.
Ravi AshwathUniversity of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Sowmya BalasubramanianCS Mott Children's Hospital, Ann Arbor, Michigan, USA.
David M BikoChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sujatha BuddheSeattle Children's Hospital, Seattle, Washington, USA.
M Jay CampbellDuke Children's Hospital, Durham, North Carolina, USA.
Russell CrossChildren's National Medical Center, Washington, DC, USA.
Pierluigi FestaFondazione G. Monasterio C.N.R. Regione Toscana, Pisa, Italy.
Lindsay GriffinAnn & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Heynric GrotenhuisUniversity of Utrecht, Utrecht, the Netherlands.
Keren HasbaniDell Children's Medical Center, Austin, Texas, USA.
Sassan HashemiChildren's Healthcare of Atlanta, Atlanta, Georgia, USA.
Sanjeet HegdeRady Children's Hospital San Diego, San Diego, California, USA.
Tarique HussainChildren's Medical Center Dallas, Dallas, Texas, USA.
Supriya JainMaria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, USA.
Maria KiaffasChildren's Mercy Hospital, Kansas City, Missouri, USA.
Shelby KuttyJohns Hopkins Children's Center, Baltimore, Maryland, USA; Children's Hospital and Medical Center, Omaha, Nebraska, USA.
Christopher Z LamHospital for Sick Children, Toronto, Canada.
Gabriela LiberatoHeart Institute, InCor, Sao Paulo, Brazil.
Anthony MerloccoLe Bonheur Children's Hospital, Memphis, Tennessee, USA.
Nilanjana MisraCohen Children's Medical Center of New York, Northwell Health, New Hyde Park, New York, USA.
Katie L MowersCS Mott Children's Hospital, Ann Arbor, Michigan, USA; St Louis Children's Hospital, St Louis, Missouri, USA.
Juan Carlos MunizNicklaus Children's Hospital, Miami, Florida, USA.
Arni NuttingMedical University of South Carolina, Charleston, South Carolina, USA.
David A ParraVanderbilt Children's Hospital, Nashville, Tennessee, USA.
Jyoti K PatelRiley Children's Hospital, Indianapolis, Indiana, USA.
Antonio R Perez-AtaydeBoston Children's Hospital, Boston, Massachusetts, USA.
Deepa PrasadBanner Children's Hospital, Mesa, Arizona, USA.
Carlos F RosentalHospital Pediatria Garrahan, Buenos Aires, Argentina.
Amee ShahChildren's Hospital of New York, New York, New York, USA.
Margaret M SamynMedical Collect of Wisconsin/Children's Wisconsin, Milwaukee, Wisconsin, USA.
Lynn A SleeperBoston Children's Hospital, Boston, Massachusetts, USA.
Timothy SlesnickChildren's Healthcare of Atlanta, Atlanta, Georgia, USA.
Emanuela ValsangiacomoUniversity Children's Hospital Zurich, Zurich, Switzerland.
Tal GevaBoston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USChildren's Healthcare of Atlanta · USBanner Desert Medical Center · USChildren's Hospital of Philadelphia · USChildren's Hospital of Wisconsin · USChildren's Medical Center · USChildren's Mercy Hospital · USChildren's National · USCohen Children's Medical Center · USC. S. Mott Children's Hospital · USDell Children's Medical Center of Central Texas · USDuke Children's Hospital & Health Center · USFondazione Toscana Gabriele Monasterio · ITGarrahan Hospital · ARHospital for Sick Children · CAJohns Hopkins University · USLe Bonheur Children's Hospital · USLower Manhattan Hospital · USLurie Children's Hospital · USMedical University of South Carolina · US

Funding

The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023
$5.0M
NHLBI NIH HHS R01 HL121754
6 · The paper itself

Abstract

backgroundAfter diagnosis of a cardiac mass, clinicians must weigh the benefits and risks of ascertaining a tissue diagnosis. Limited data are available on the accuracy of previously developed noninvasive pediatric cardiac magnetic resonance (CMR)-based diagnostic criteria.

objectivesThe goals of this study were to: 1) evaluate the CMR characteristics of pediatric cardiac masses from a large international cohort; 2) test the accuracy of previously developed CMR-based diagnostic criteria; and 3) expand diagnostic criteria using new information.

methodsCMR studies (children 0-18 years of age) with confirmatory histological and/or genetic diagnosis were analyzed by 2 reviewers, without knowledge of prior diagnosis. Diagnostic accuracy was graded as: 1) single correct diagnosis; 2) correct diagnosis among a differential; or 3) incorrect diagnosis.

resultsOf 213 cases, 174 (82%) had diagnoses that were represented in the previously published diagnostic criteria. In 70% of 174 cases, both reviewers achieved a single correct diagnosis (94% of fibromas, 71% of rhabdomyomas, and 50% of myxomas). When ≤2 differential diagnoses were included, both reviewers reached a correct diagnosis in 86% of cases. Of 29 malignant tumors, both reviewers indicated malignancy as a single diagnosis in 52% of cases. Including ≤2 differential diagnoses, both reviewers indicated malignancy in 83% of cases. Of 6 CMR sequences examined, acquisition of first-pass perfusion and late gadolinium enhancement were independently associated with a higher likelihood of a single correct diagnosis.

conclusionsCMR of cardiac masses in children leads to an accurate diagnosis in most cases. A comprehensive imaging protocol is associated with higher diagnostic accuracy.

Indexed as

Contrast MediaHeart NeoplasmsChildGadoliniumHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CinePredictive Value of TestsRetrospective StudiesContrast MediaGadoliniumcardiac magnetic resonancecardiac masscardiac tumorpediatric

Identifiers

PMID34419404
PMCPMC11240235
OpenAlexW3194468737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.