ArticleJACC. Cardiovascular imaging2022
Association of Regional Wall Shear Stress and Progressive Ascending Aorta Dilation in Bicuspid Aortic Valve.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Thoracic Aortic Aneurysm Growth Rates and Predicting Factors: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Mitral valve regurgitation assessed by intraventricular CMR 4D-flow: a systematic review on the technological aspects and potential clinical applications.The international journal of cardiovascular imaging · 2023Pooled it
- 4D-flow MRI derived wall shear stress for the risk stratification of bicuspid aortic valve aortopathy: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Backward Aortic Flow Is Associated with Impaired Left Ventricular Mechanics in Young Adults with Bicuspid Aortic Valve: A Prospective Cardiovascular Magnetic Resonance Study.Journal of clinical medicine · 2026Article
- Altered caval flow and wall shear stress in single ventricle circulation: insights from ferumoxytol-enhanced 4D flow MRI.European heart journal. Imaging methods and practice · 2026Article
- Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).Molecular medicine reports · 2026Review
- Numerical simulations to predict complication after coarctation repair starting from 4D-Flow magnetic resonance imaging.The international journal of cardiovascular imaging · 2026Article
- Longitudinal 4D Flow MRI-Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm.Journal of magnetic resonance imaging : JMRI · 2026Article
- 4D Flow Cardiovascular Magnetic Resonance Uncovers the Hemodynamic Clue in Aortic Dissection.JACC. Case reports · 2026Article
- Hemodynamic factors of aortic dilatation after thoracic endovascular aortic repair for type-B aortic dissection.Frontiers in bioengineering and biotechnology · 2026Article
- 4D Flow MRI derived aortic pulse wave velocity and wall shear stress in Covid-19.Clinical imaging · 2025Article
- A Fully Automated Analysis Pipeline for 4D Flow MRI in the Aorta.Bioengineering (Basel, Switzerland) · 2025Article
- Emerging imaging and circulating biomarkers in relation to underlying mechanisms in Bicuspid Aortic Valve aortopathy.International journal of cardiology. Heart & vasculature · 2025Review
- Article
- Comprehensive assessment of aortic flow before and after aortic valve replacement in an ex vivo porcine model with four-dimensional flow magnetic resonance imaging.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Microinjection of angiotensin II into zebrafish embryos induces transient dilation and elastin disruption of the dorsal aorta.Physiological reports · 2025Article
- Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve.The international journal of cardiovascular imaging · 2025Article
- Cardiovascular magnetic resonance 4D flow derived aortic and pulmonary wall shear stress in pediatric patients with repaired tetralogy of Fallot.Frontiers in pediatrics · 2025Article
- Aortopathy associated with bicuspid aortic valve: advances in clinical and hemodynamics research.Frontiers in physiology · 2025Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this study was to evaluate the role of wall shear stress (WSS) as a predictor of ascending aorta (AAo) growth at 5 years or greater follow-up.
backgroundAortic 4-dimensional flow cardiac magnetic resonance (CMR) can quantify regions exposed to high WSS, a known stimulus for arterial wall dysfunction. However, its association with longitudinal changes in aortic dilation in patients with bicuspid aortic valve (BAV) is unknown.
methodsThis retrospective study identified 72 patients with BAV (age 45 ± 12 years) who underwent CMR for surveillance of aortic dilation at baseline and ≥5 years of follow-up. Four-dimensional flow CMR analysis included the calculation of WSS heat maps to compare regional WSS in individual patients with population averages of healthy age- and sex-matched subjects (database of 136 controls). The relative areas of the AAo and aorta (in %) exposed to elevated WSS (outside the 95% CI of healthy population averages) were quantified.
resultsAt a median follow-up duration of 6.0 years, the mean AAo growth rate was 0.24 ± 0.20 mm/y. The fraction of the AAo exposed to elevated WSS at baseline was increased for patients with higher growth rates (>0.24 mm/y, n = 32) compared with those with growth rates <0.24 mm/y (19.9% [IQR: 10.2%-25.5%] vs 5.7% [IQR: 1.5%-21.3%]; P = 0.008). Larger areas of elevated WSS in the AAo and entire aorta were associated with higher rates of AAo dilation >0.24 mm/y (odds ratio: 1.51; 95% CI: 1.05-2.17; P = 0.026 and odds ratio: 1.70; 95% CI: 1.01-3.15; P = 0.046, respectively).
conclusionsThe area of elevated AAo WSS as assessed by 4-dimensional flow CMR identified BAV patients with higher rates of aortic dilation and thus might determine which patients require closer follow-up.
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Registered trials
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