ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021
Microscale dynamics of electrophysiological markers of epilepsy.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 32 citations in OpenAlex.
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- Bridging the Gap: Integrated High-Density Microelectrode Arrays for Cellular, Organoid, and Clinical Electrophysiology.Micromachines · 2026Review
- Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays.Epilepsia · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- A modular and flexible pipeline for intraoperative electrode reconstruction and localization in patients with brain lesions.Frontiers in neural circuits · 2026Article
- Distance of bipolar re-referencing imparts nonlinear frequency-specific influences on intracranial recording signal measurements.Journal of neural engineering · 2025Article
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- Intan Technologies integrated circuits can produce analog-to-digital conversion artifacts that affect neural signal acquisition.Journal of neural engineering · 2024Article
- Differential cortical layer engagement during seizure initiation and spread in humans.Nature communications · 2024Article
- Intraoperative application and early experience with novel high-resolution, high-channel-count thin-film electrodes for human microelectrocorticography.Journal of neurosurgery · 2024Article
- Multiplexed Surface Electrode Arrays Based on Metal Oxide Thin-Film Electronics for High-Resolution Cortical Mapping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Network-motif delay differential analysis of brain activity during seizures.Chaos (Woodbury, N.Y.) · 2023Article
- Low glycemic index diet restrains epileptogenesis in a gender-specific fashion.Cellular and molecular life sciences : CMLS · 2023Article
- DREDge: robust motion correction for high-density extracellular recordings across species.bioRxiv : the preprint server for biology · 2023Article
- Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.Epilepsia · 2023Article
- Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces.MRS bulletin · 2023Article
- Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays.Science translational medicine · 2022Article
- Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.Advanced functional materials · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
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19 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveInterictal discharges (IIDs) and high frequency oscillations (HFOs) are established neurophysiologic biomarkers of epilepsy, while microseizures are less well studied. We used custom poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) microelectrodes to better understand these markers' microscale spatial dynamics.
methodsElectrodes with spatial resolution down to 50 µm were used to record intraoperatively in 30 subjects. IIDs' degree of spread and spatiotemporal paths were generated by peak-tracking followed by clustering. Repeating HFO patterns were delineated by clustering similar time windows. Multi-unit activity (MUA) was analyzed in relation to IID and HFO timing.
resultsWe detected IIDs encompassing the entire array in 93% of subjects, while localized IIDs, observed across < 50% of channels, were seen in 53%. IIDs traveled along specific paths. HFOs appeared in small, repeated spatiotemporal patterns. Finally, we identified microseizure events that spanned 50-100 µm. HFOs covaried with MUA, but not with IIDs.
conclusionsOverall, these data suggest that irritable cortex micro-domains may form part of an underlying pathologic architecture which could contribute to the seizure network. SIGNIFICANCE: These results, supporting the possibility that epileptogenic cortex comprises a mosaic of irritable domains, suggests that microscale approaches might be an important perspective in devising novel seizure control therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.