Evidence map›Paper›PMID 34419042›Full record

ArticleBMC endocrine disorders2021

Elevated lactate in Mauriac syndrome: still a mystery.

Brice Touilloux, Henri Lu, Belinda Campos-Xavier, Andrea Superti-Furga, Michael Hauschild, Thérèse Bouthors, Christel Tran

Erratum issuedOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Persistent Lactatemia in Mauriac Syndrome.Case reports in endocrinology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brice TouillouxCenter for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Henri LuService of Cardiology, Department of Cardio-Vascular Medicine and Surgery, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Belinda Campos-XavierCenter for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Andrea Superti-FurgaCenter for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Michael HauschildPediatric Endocrinology, Diabetology and Obesity Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Thérèse BouthorsPediatric Endocrinology, Diabetology and Obesity Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Christel TranCenter for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland. christel.tran@chuv.ch.ORCID http://orcid.org/0000-0003-4158-536X
University of Lausanne · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Mauriac syndrome was described in 1930 as a peculiar combination of poorly controlled diabetes mellitus type 1, stunted growth and glycogenic hepatopathy. More recently, lactic acidosis was recognized as an additional feature, often induced by insulin treatment. CASE PRESENTATION: A 17-year old girl known for diabetes type 1A and Mauriac syndrome was admitted to the emergency room with hyperglycemia of > 41 mmol/l without ketoacidosis. Under a standard insulin regimen, hyperglycemia was rapidly corrected but marked hyperlactatemia occurred.

conclusionsThe mechanism of impaired glucose utilization and lactate elevation independent of ketoacidosis in Mauriac syndrome is intriguing. The rarity of Mauriac syndrome and its resemblance to glycogen storage diseases suggest the presence of a specific metabolic or genetic predisposition that remains to be identified.

Indexed as

AdolescentDiabetes ComplicationsDiabetes Mellitus, Type 1FemaleHepatomegalyHumansHyperlactatemiaLactatesPrognosisLactatesElevated lactateGlycogenic hepatopathyMauriac syndrome

Identifiers

PMID34419042
PMCPMC8379780
OpenAlexW3195589190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.