Evidence map›Paper›PMID 34419006›Full record

ArticleBMC nephrology2021

Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the FAITH on fistula trial.

K Lindhard, M Rix, J G Heaf, H P Hansen, B L Pedersen, B L Jensen, D Hansen

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04011072 (Effect of Far Infrared Therapy on Arteriovenous Fistulas Maturation, Survival and Stenosis. A Randomized, Controlled Open-labeled Multicenter Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04011072 nacompletednot on this map

Effect of Far Infrared Therapy on Arteriovenous Fistulas Maturation, Survival and Stenosis. A Randomized, Controlled Open-labeled Multicenter Study

TypeinterventionalSponsorHerlev and Gentofte HospitalRan2019 to 2023Enrolled206ConditionsArterio-venous FistulaArmsFar infrared radiation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K LindhardDepartment of Nephrology, Herlev Hospital, Borgmester Ib Juels Vej 1, DK-2730, Herlev, Denmark. Kristine.lindhard.rasmussen@regionh.dk.ORCID 0000-0003-2471-2056
M RixDepartment of Nephrology, Rigshospitalet, Copenhagen, Denmark.
J G HeafDepartment of Nephrology, University hospital of Zealand, Roskilde, Denmark.
H P HansenDepartment of Nephrology, Herlev Hospital, Borgmester Ib Juels Vej 1, DK-2730, Herlev, Denmark.
B L PedersenDepartment of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark.
B L JensenDepartment of cardiovascular and renal research, University Hospital of Southern Denmark, Odense, Denmark.
D HansenDepartment of Nephrology, Herlev Hospital, Borgmester Ib Juels Vej 1, DK-2730, Herlev, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis treatment. After creation many of the AVFs will never mature or if functioning will need an intervention within 1 year due to an AVF stenosis. Studies investigating possible therapies that improves the AVF maturation and survival are scarce. Far infrared therapy (FIR) has shown promising results. In minor single centre and industry supported trials FIR has shown improved AVF maturation and survival. There is a need of a randomized multicentre controlled trial to examine the effect of FIR on the AVF maturation and survival and to explore the possible AVF protective mechanism induced by the FIR treatment.

methodsThis investigator initiated, randomized, controlled, open-labeled, multicenter clinical trial will examine the effect of FIR on AVF maturation in patients with a newly created AVF (incident) and AVF patency rate after 1 year of treatment in patients with an existing AVF (prevalent) compared to a control group. The intervention group will receive FIR to the skin above their AVF three times a week for 1 year. The control group will be observed without any treatment. The primary outcome for incident AVFs is the time from surgically creation of the AVF to successful cannulation. The primary outcome for the prevalent AVFs is the difference in number of AVFs without intervention and still functioning in the treatment and control group after 12 months. Furthermore, the acute changes in inflammatory and vasodilating factors during FIR will be explored. Arterial stiffness as a marker of long term AVF patency will also be examined. DISCUSSION: FIR is a promising new treatment modality that may potentially lead to improved AVF maturation and survival. This randomized controlled open-labelled trial will investigate the effect of FIR and its possible mechanisms.

trial registrationClinicaltrialsgov NCT04011072 (7th of July 2019).

Indexed as

Arteriovenous Shunt, SurgicalCatheterizationInfrared RaysKidney Failure, ChronicRenal DialysisAdultConstriction, PathologicHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicVascular PatencyArteriovenous fistulaAVF maturationAVF patencyHemodialysisInfrared therapy

Identifiers

PMID34419006
PMCPMC8379732

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.